Hydrogen Water Benefits: Small, Mixed Shifts in Blood Markers, and No Significant Win in the Three Biggest Trials

Fill a bottle with ordinary water, push hydrogen gas into it, and you have the most hyped drink of the decade. The sellers say it is an antioxidant that fights inflammation and ageing, lifts your energy, speeds recovery, lowers cholesterol and blood sugar, and helps your skin and your brain. And they point to Japan, where it has been sold for years [1].

Here is the short answer. The gas is real, and so is the research: we found 41 randomised trials outside sport that compared it with plain water or a dummy, one of them a preprint not yet peer reviewed, and more in athletes. In small trials, a few blood markers of inflammation and oxidation moved the right way, others did not differ significantly from plain water, and in two they moved the wrong way. Cholesterol fell a little in two of three poolings of the trials. And in the three biggest trials, of 700, 200 and 178 people, hydrogen water was not significantly better than a dummy on the thing each trial set out to measure. We rate the claim that hydrogen water reduces inflammation and oxidative stress Preliminary.

This is journalism, not medical advice. If you manage a chronic illness, such as diabetes, high cholesterol or Parkinson’s disease, do not swap a prescribed treatment for hydrogen water: the trials in those conditions added it on top of usual care, and the newest pooling of the cholesterol trials says it should not delay or replace proven treatment [2]. Ask your clinician before relying on it.

People want to know. “Hydrogen water benefits” is searched about 18,100 times a month in the US, the database’s figure for the past year; the latest month, September 2026, was 14,800, and October and December 2025 and January 2026 each ran at 27,100; “does hydrogen water work” is searched about 320 times a month (from a paid keyword database, pulled 23 October 2026) [1].

What is hydrogen water, and how much hydrogen is in it?

Hydrogen water is water with hydrogen gas dissolved in it: the two-atom molecule, H2, not the hydrogen already locked inside every water molecule. It has no taste, colour or smell, which matters later. Water can only hold a little of it. At room temperature and ordinary pressure, a litre holds at most about 1.6 mg, or 1.6 ppm (parts per million, the same thing as milligrams per litre) [3]. So a full 8-ounce glass (237 mL) of saturated water carries at most about 0.4 mg of hydrogen, by our arithmetic. Water under pressure, or fresh from a tablet, can hold more for a while, which is how some trials in the table below give figures of 7 ppm and more; the extra leaves once the water meets ordinary air, as the next paragraphs show.

And it does not stay put. Japan’s National Consumer Affairs Center tested ten packaged hydrogen waters and nine generators in 2016 [4]. In three of the five brands that printed a concentration at filling or shipping, the water held less than the label said. Two brands in plastic bottles that printed no figure held no detectable hydrogen at all. Opened and re-capped, the packaged waters kept 30 to 60% of their hydrogen after five hours and about 10% after a day; water from a generator, poured into a cup, kept 50 to 60% after an hour [4].

Tablets work differently. They hold magnesium metal and an acid; dropped in water, the magnesium reacts and gives off hydrogen. In one trial’s measurement, a tablet in 17 fl oz (500 mL) briefly pushed the water to about 10 mg/L, above what water can normally hold, and it fell back to 1.6 mg/L within 30 minutes [5]. The trials gave anything from about a third of a milligram a day to about 24 mg, by our arithmetic from their methods [6] [7].

One thing to keep separate. Hydrogen is also given as a gas to breathe, in hospitals. In a Japanese trial of 73 patients in a coma after a cardiac arrest, they breathed 2% hydrogen with their oxygen for 18 hours; the main result, a good brain outcome at 90 days, was 56% against 39% and not statistically significant [8]. That is a different dose, by a different route, in a different situation. Nothing on this page is about it.

Do the Japanese drink hydrogen water?

Some do, and enough to keep the regulators busy. The 2016 test picked its products from the popularity rankings of big online shops and from big stores and convenience stores; by then Japan’s consumer centres had logged 2,260 enquiries about drinking hydrogen water since 2011, rising each year [4]. The centre found sellers’ websites claiming that hydrogen “renders harmless the bad active oxygen said to cause various diseases” (our translation), and warned that such claims could breach three Japanese laws. It noted that no hydrogen water had been approved as a government-recognised health food, and that hydration was the effect the companies themselves most often named [4].

In March 2021 Japan’s Consumer Affairs Agency went further. It ordered four companies selling or renting hydrogen-water machines not to repeat, without a reasonable basis, claims that the water removed harmful active oxygen and so prevented ageing, cancer, skin spots and wrinkles, atopic eczema, inflammation and allergy, and diseases from diabetes to brain disease [9]. Three of the four sent in evidence. The agency did not accept any of it as a reasonable basis for the claims [9].

Does hydrogen water reduce inflammation and oxidative stress?

First, the words. Oxidative stress is the wear that reactive forms of oxygen, often called free radicals, do to the body’s fats, proteins and DNA. An antioxidant mops them up. Neither is easy to measure in a living person, so trials measure stand-ins in the blood: MDA, a breakdown product of damaged fats; d-ROMs, a measure of oxidised compounds; antioxidant capacity; and, for inflammation, signals the immune system sends, such as IL-6, TNF and CRP. A shift in one of these is not the same as feeling better or living longer. It is the evidence the claim rests on most directly, though.

The science behind it started in a lab. In 2007 a Japanese medical school reported that hydrogen “selectively reduced” the most damaging radical in cell dishes, and that rats breathing the gas suffered markedly less brain injury after a blocked artery was reopened [10]. That was gas, inhaled, in an acute injury. The drinking trials came after.

In healthy people the cleanest test is a Korean one: 41 adults drank 51 fl oz (1.5 L) a day of bottled hydrogen water or plain water for four weeks, without knowing which [11]. The oxidation and antioxidant markers did not differ significantly between the groups; antioxidant capacity rose in both. The hydrogen group had fewer dying white blood cells, and genes linked to inflammation were less active in them [11]. The authors’ headline was that hydrogen water “reduces inflammatory responses”. Their own main markers of oxidation did not show it. A second Korean trial ran twice as long. 65 hospital staff were assigned to drink 51 fl oz (1.5 L) a day for eight weeks from machines at work that either made electrolysed water carrying about 0.59 mg/L of hydrogen or only filtered it, without knowing which [12]. Its main outcome was a set of oxidation markers. Oxidised compounds (d-ROMs) ended lower on hydrogen water, but that group had also started lower, 301 units against 347; antioxidant capacity was ahead on hydrogen at four weeks and behind at eight; four other markers were not significantly different between the groups, and two antioxidant enzymes it named among its main outcomes, SOD and catalase, are not reported in the paper or its supplement [12].

In people who were ill, the results point both ways. In 60 Indian adults with metabolic syndrome, three hydrogen tablets a day for 24 weeks beat dummy tablets on cholesterol, blood sugar and inflammation markers, though not on one oxidation marker [13]. The tablet maker donated the tablets and paid part of the costs. In 73 people with raised blood sugar analysed in a Chinese trial, IL-6 and TNF fell by much the same amount on hydrogen water and on plain water [14]. In the 181 analysed in the biggest metabolic trial, CRP and TNF did not differ significantly between hydrogen water and filtered water [15].

And in two trials an oxidation marker moved the wrong way. In 30 people with fatty liver disease, MDA rose on hydrogen tablets and fell on dummy tablets; the paper’s results section reports that difference as significant, and its summary calls it a non-significant tendency [16]. In 60 people with chronic mountain sickness in Tibet, oxidative stress was the main outcome: after eight weeks MDA had risen more on hydrogen water than on placebo water, by 2.11 units, with a confidence interval (the range the true average probably sits in) from 1.13 to 3.09 [17]. Antioxidant capacity rose more on hydrogen water too, by 2.86 units, from 0.09 to 5.64, and the authors read the result as both a pro-oxidant and an antioxidant effect; they concluded that it “did not reduce oxidative stress-induced damage”. A second Tibetan trial, of 50 people, found only a downward trend in the markers, not significant [18].

The only pooling of these markers in people alone that we found is in exercise. It combined six studies of 76 healthy adults who took hydrogen as water, a bath or a gas around hard exercise [19]. On d-ROMs the pooled difference was −0.01, a standardised difference: the gap measured in units of how much people varied, where 0.2 is what researchers call small and 0.8 large. Its confidence interval ran from −0.42 to 0.39, so it could not tell hydrogen from a dummy. Antioxidant capacity came out 0.29 higher, from 0.04 to 0.54: small, and just clear of no difference [19]. A 2022 pooling for gum disease reported large falls in inflammation markers on hydrogen water, but only 4 of its 17 studies were in people; the rest were in rats and mice, or in cells and bacteria in the lab, so it says little about people drinking the water [20].

Here is every trial outside sport we found that randomised people to hydrogen water or tablets against plain water or a dummy [21].

Every randomised trial outside sport we found that compared hydrogen water or tablets with plain water or a dummy
Who, and for how longWhat they drank, against whatMain or headline resultWho paid or supplied
700 adults with Covid-19 (675 analysed), France and Serbia, 21 days [22]A tablet in 8.5 fl oz (250 mL) of water twice a day; dummy tablets fizzed alike, with magnesium carbonate in place of magnesium metalWorse by day 14: 46.1% on hydrogen, 43.5% on the dummy; not significantPart-funded by the tablet maker, with public and charitable money
200 adults with or near metabolic syndrome (181 analysed), Japan, 3 months [15]Water from a home electrolysis machine; identical machines that only filteredWaist size, the main outcome, and every secondary outcome: no significant differenceFunded by the machine maker; one author its employee
178 people with Parkinson’s disease, Japan, 72 weeks [23]34 fl oz (1 L) a day of bottled hydrogen water; water saturated with nitrogenSymptom score, the main outcome: no significant difference, by two later accounts (we could not read the trial’s own report)Japanese public grant; water from two hydrogen-water companies
144 people on chemotherapy for bowel cancer (136 analysed), China [24]Water given hydrogen in the hospital’s lab, 0.27 to 0.4 ppm; placebo water; single-blindLiver enzymes rose significantly on placebo, not significantly on hydrogen waterA city science and technology fund (Tai’an)
114 people with high uric acid (100 analysed), China, 8 weeks [3]Two or three 11 fl oz (330 mL) cans a day; the same cans of plain water; participants blindedHigher dose: uric acid fell against its own start; lower dose not significantly different from plain waterPublic grants; the cans supplied by a hydrogen-water company
106 people with raised fasting blood sugar (73 analysed), China, 8 weeks [14]34 fl oz (1 L) a day of packaged hydrogen water; plain water from the same companyFasting sugar fell in both groups, more on hydrogen; IL-6 and TNF fell by similar amounts in bothPublic grants; both waters from a hydrogen-water company
106 people with kidney stones in four groups, China, 12 weeks [25]68 fl oz (2 L) a day from a generator cup; plain water; not blindedHydrogen water alone: treatment “effective” in 32% against 28% on plain waterPublic grants; the generators provided by a nanobubble company
84 people with reflux disease, Italy, 3 months [26]Electrolysed water from a home device plus their usual drug; tap water plus the drug; blinding not describedSymptoms and oxidation markers betterItalian ministry; the device lent by a named individual
81 people with mild memory problems (73 analysed), Japan, 1 year [6]About 10 fl oz (300 mL) a day from pouches; placebo water in identical pouchesMemory score, the main outcome: no significant difference; one gene-variant subgroup did betterPublic grants; both waters given by a hydrogen-water company the senior author had advised from 2005 to 2008
72 women with premenstrual syndrome (65 analysed), Turkey, three cycles [27]51 to 68 fl oz (1.5 to 2 L) a day from a portable generator bottle; bottled water in a look-alike bottleSymptom scores lower on hydrogen waterUniversity grant; no competing interests declared
68 healthy volunteers, Japan, 2 weeks [28]17 fl oz (500 mL) a day at over 7 ppm in a pressurised bottle; bottles filled with nitrogenA finger test of blood-vessel function improved more on hydrogenNo funding; authors include doctors at a hydrogen clinic
68 people with high cholesterol, China, 10 weeks [29]30 fl oz (0.9 L) a day; placebo waterHDL worked better in lab tests; more people saw cholesterol fallSummary only; funding not read
65 healthy hospital staff (53 analysed), Korea, 8 weeks [12]51 fl oz (1.5 L) a day of electrolysed water at about 0.59 mg/L; filtered water from the same machinesOxidation markers, the main outcome: d-ROMs lower on hydrogen in a group that started lower; antioxidant capacity ahead at 4 weeks, behind at 8; four others not significantly different; two more it named as main outcomes not reportedA health foundation; the machines that made both waters installed by their maker, whose engineer also put up the labels that kept the groups blind; no conflicts declared
60 adults with metabolic syndrome, India, 24 weeks [13]Three tablets a day; dummy tablets alike in taste, fizz and lookCholesterol, sugar and inflammation markers better than on the dummy; one oxidation marker notTablets donated, and the trial part-funded, by the tablet maker; lead author paid fees on hydrogen
60 people with chronic mountain sickness (59 analysed), Tibet, 8 weeks [17]33 fl oz (990 mL) a day; placebo waterOxidative stress, the main outcome: a damage marker and antioxidant capacity both rose more on hydrogen; side effects 50% against 37%Summary only; no competing interests declared
60 adults, Japan, 4 weeks [30]Alkaline electrolysed water (0.2 mg/L of hydrogen) from modified home units; purified tap water from the same unitsNo clear effect; more said they slept soundlyTwo authors employees of the appliance maker
60 men at risk of artery disease (59 in its results), China, 10 weeks [31]Three 8.3 fl oz (245 mL) bottles a day; identical bottles of pure waterArtery stiffness, MDA and SOD not significantly different at 10 weeks; total cholesterol ended lower on hydrogen than on plain water (P = 0.047), because it rose significantly on plain water and not significantly on hydrogen; one of four oxidised fats, measured only at the end, was lower on hydrogenPublic grants; the water bought from a hydrogen-water company. A preprint, not peer reviewed
52 active men, Serbia, 14 days [32]68 fl oz (2 L) a day; tap waterBlood very slightly more alkalineSummary only; funding not read
50 people with type 2 diabetes, Japan, 3 months [33]Water from an electrolysis machine; filtered water from look-alike machinesInsulin resistance, the main outcome: no significant differenceFunded by the machine maker; two authors its employees
50 people with chronic high-altitude disease (43 analysed), Tibet, 60 days [18]Hydrogen water; placebo waterOxidative-stress and inflammation markers: a downward trend, not significantSummary only; no competing interests declared
49 people having radiotherapy for liver tumours, Korea, 6 weeks [34]A magnesium stick in bottled water; an empty stick; blinding not describedQuality of life better; an oxidation marker lowerA Japanese foundation’s grant
41 healthy adults (38 analysed), Korea, 4 weeks [11]51 fl oz (1.5 L) a day of bottled hydrogen water at 0.75 ppm; bottled plain waterAntioxidant and oxidation markers: no significant difference; fewer dying blood cells on hydrogenPart-funded by the water-purifier company whose plain water was used
40 active adults, Poland, 8 weeks [35]Alkaline “redox” water from a generator; bottled water with the same labelIL-6 straight after a hard exercise test lower; the groups started unequalFunded by the generator company
40 people in hospital with unstable angina, China, 3 months [36]34 to 41 fl oz (1 to 1.2 L) a day from an electrolysis cup; pure waterChest-pain symptoms and cholesterol fell more on hydrogenPublic grants; no conflicts declared
40 adults aged 70 and over, Serbia, 6 months [37]17 fl oz (0.5 L) a day at 15 ppm; water with noneTelomere length better (P = 0.049) among dozens of outcomes; most others not significantly differentSummary only; funding not read
36 adults with obesity (35 analysed), Serbia, 8 weeks [38]34 fl oz (1 L) a day carrying 15 mg of hydrogen; tap waterCravings, the main outcome, lower (P = 0.05); total and LDL cholesterol lowerPart-funded and supplied by a hydrogen-product company; one author its employee
36 people with type 2 diabetes or prediabetes, Japan, 8 weeks each way (crossover) [39]30 fl oz (900 mL) a day; placebo waterModified LDL and a urine oxidation marker fell; other markers only trendedSummary only; funding not read
34 healthy volunteers, Japan, one drink [40]17 fl oz (500 mL) at over 7 ppm; a nitrogen-filled bottle with a dummy insertAn artery-widening test better than on placeboOne author works for a maker of hydrogen generators; water from a hydrogen-water company
32 people with long Covid, China, 14 days [41]Water from an electrolysis device; placebo water in the same packaging; participants blindedFatigue score and walking test better; breathlessness not significantly differentNo external funding
30 people with fatty liver disease, Slovakia, 8 weeks [16]Three tablets a day; dummy tablets that fizzed with carbon dioxideMostly no significant differences; an oxidation marker (MDA) rose on hydrogen and fell on the dummyPart-funded by the tablet maker, which supplied both tablets
30 people with painful bladder syndrome (28 finished), Japan, 8 weeks [42]Hydrogen water or placebo water in pouches, two to oneSymptoms: not significantly different from placeboA public-health research foundation; both waters obtained from a drug company
27 adults over 50 starting weight training, Serbia, 6 weeks [7]Two servings a day, 12 mg each; water with almost noneMuscle-damage markers and cholesterol lowerSummary only; one author works for a hydrogen-product company
26 adults, Japan, 4 weeks each way (crossover) [43]20 fl oz (600 mL) a day from pouches; the same mineral water without hydrogenA distress score and resting nerve activity lowerFunded by, and both waters from, a hydrogen-water company
25 women with panic disorder, Spain, 3 months [44]51 fl oz (1.5 L) a day at 1.2 ppm from a home generator, plus therapy; look-alike machines giving ordinary water, plus therapyNot significantly better than placeboNo grant; the company whose generator was used installed it, and its manager is an author
24 healthy adults, Czech Republic, one session each way (crossover) [45]43 fl oz (1.26 L) in 15 minutes; hydrogen-free waterEye pressure rose on both, not significantly different; more large individual rises on hydrogenSummary only; funding not read
22 people with muscle diseases, Japan, 8 weeks each way (crossover) [46]17 fl oz (500 mL) a day at about 0.5 ppm; placebo waterNo objective clinical effect; one blood marker better in one diseaseJapanese government grants; both waters bought from a hydrogen-water company
21 people with keloid scars, China [47]Hydrogen in their drinking water; hydrogen-free waterPain, itch and scar scores lower after hydrogen water; the summary gives no comparison with the other groupSummary only; a hospital grant
20 men, Japan, 2 weeks [48]17 fl oz (500 mL) a day of alkaline electrolysed water at 0.3 mg/L; purified tap waterStools closer to “normal”; one gut bacterium more commonOne author an employee of the appliance maker
16 sleep-deprived adults, Serbia, one drink each way (crossover) [49]Tablet water at 8 ppm; tap waterFaster on a pen-and-paper attention testPublic funds and the tablet maker, which supplied the tablets
12 people with fatty liver disease, Serbia, 28 days each way (crossover) [50]34 fl oz (1 L) a day; placebo waterLiver fat lowerSummary only; funding not read
10 overweight women, Serbia, 4 weeks each way (crossover) [51]Hydrogen-making caplets; dummy capletsBody fat and triglycerides lowerSummary only; its grants include one from a US company
41 trials, largest first by the number who took part; one of them, marked, is a preprint that has not been peer reviewed. Bold rows (22 trials): by the paper’s own statements, a company that makes, sells or supplies hydrogen water, tablets or machines, or sells hydrogen treatment, paid for the trial, employed an author, or was where the trial got what was drunk or the machine that made it (given, supplied, “obtained from” it or installed by it), unless the paper says it was bought; a product the paper only names is not counted. In 10 others we read only the published summary and could not check. A ppm (part per million) of hydrogen is a milligram in a litre. Trials of exercise performance are pooled in the section on recovery. Left out: trials of hydrogen jellies, capsules, baths, gargles and gas; trials whose comparison group drank no study water at all, such as usual care alone; and trials of alkaline or “reduced” waters whose papers report no dissolved hydrogen gas.

Read down the right-hand column. In 22 of these 41 trials a company that makes, sells or supplies hydrogen water, tablets or machines, or sells hydrogen treatment, paid for the work, employed an author, or was where the trial got what people drank or the machine that made it, by the papers’ own statements; we did not count water a paper says was bought. That does not make their numbers wrong. It is why we read the numbers rather than the conclusions. The good news for the trials is that hydrogen has no taste, so a fair dummy is easy to make: nitrogen water, degassed water, or a tablet that fizzes without making hydrogen [52] [16].

What did the biggest trials find?

The biggest is French and Serbian. In 2021 and 2022, 700 adults with mild or moderate Covid-19 were given hydrogen tablets or dummy tablets, to dissolve in water twice a day for 21 days [22]. The dummy fizzed the same way, with magnesium carbonate in place of the magnesium metal. By day 14, 46.1% of the hydrogen group and 43.5% of the dummy group had got worse; the trial’s test could not tell those apart [22]. The tablet maker was among the funders. The authors suggest their measure of getting worse, mostly fatigue and breathlessness, may have been too soft.

The second is the Japanese metabolic trial: 200 adults with or near metabolic syndrome were sent home with identical machines, half of which made hydrogen water by electrolysis and half of which only filtered [15]. After three months, waist size, the main outcome, and every secondary outcome showed no significant difference. The machine maker paid for it. The authors then split the groups by how active people were, and reported a smaller waist on hydrogen water only in the most active, a subgroup result: a slice of the trial picked after the main test had come back empty [15].

The third is the one the Parkinson’s story rests on. A 2013 pilot gave 34 fl oz (1 L) a day of hydrogen water or a dummy for 48 weeks and, in the 17 patients it reported on, found a significant difference in their symptom score [53]. So the same team ran a bigger one: 178 patients in 14 hospitals, 72 weeks, against water saturated with nitrogen [52]. It found no significant difference in the symptom score [54] [55]. We could not read that 2018 report itself, which sits behind a paywall; its result here is as the trial’s own lead author and a 2025 review describe it [23].

The fourth biggest went the other way. In 144 Chinese patients on chemotherapy for bowel cancer, liver enzymes rose significantly in the placebo group and not significantly in the group drinking hydrogen water made in the hospital lab [24]. It was single-blind, not double-blind. It has not been repeated in any trial we found.

Does hydrogen water lower cholesterol?

A little, in some trials, and it depends who pools them. A pooling, or meta-analysis, combines trials to get one estimate. Three have pooled the cholesterol trials, and they disagree.

Three poolings of the cholesterol trials, three answers
PoolingWhat went inTotal cholesterolLDL
2026 [2]13 comparisons from 11 trials, 757 people as the pooling counts them, adults with overweight or obesity6.71 mg/dL lower, from 3.04 to 10.383.21 mg/dL lower, from 0.10 to 6.31
2024 [56]8 trials, 357 people with metabolic disordersNot significantly differentNot significantly different
2023 [57]7 trials in clinical populationsLower, a small standardised differenceLower, a small standardised difference
Ranges are 95% confidence intervals: the range the true average probably sits in, not the range of what would happen to you. The 2024 pooling found triglycerides lower instead. The 2023 pooling was written by a research group that ran several of the trials in it.

The newest and biggest, from 2026, pooled 13 comparisons, from 11 trials, in what it counts as 757 adults with overweight or obesity [2]. Total cholesterol came out 6.71 mg/dL lower on hydrogen water, with a range from 3.04 to 10.38 lower; LDL, the “bad” cholesterol, 3.21 mg/dL lower, from 0.10 to 6.31; HDL, the “good” kind, 1.16 mg/dL lower too; triglycerides not significantly different [2]. The authors rate the evidence for total and LDL cholesterol as moderate in certainty, and call the falls far below what would matter for heart disease: they put the smallest change in LDL that matters at 10 to 15 mg/dL for lifestyle changes and 30 mg/dL for a statin [2].

Before we print a pooled figure we look for the biggest trial inside it. Here it is the Japanese metabolic trial, with nearly a fifth of the weight [2]. Its own table shows total cholesterol 7.18 mg/dL lower after three months on hydrogen water and 1.22 lower on filtered water, a difference that was not significant; and the hydrogen group had started about 15 mg/dL higher [15]. The pooling’s chart row matches that, −5.96 [2].

We found two problems in the pooling’s list. The 2022 and 2023 rows from Slovakia are the same 30 patients, counted twice [16] [58]. And the two Chinese uric-acid rows share one group of 32 people on plain water [3]. We re-ran the pooling from the numbers printed on its chart, by the method it names. As printed we get 6.72 mg/dL lower. Counting the Slovak patients once and keeping one of the Chinese comparisons gives 7.16 or 7.75 lower, depending which. So the double counting does not explain the result away. That is our arithmetic, not the authors’, and we mark it as ours.

The 2024 pooling, of eight trials and 357 people with metabolic disorders, found total and LDL cholesterol not significantly different, and triglycerides slightly lower [56]. The 2023 pooling found all three lower [57]; its authors ran several of the trials in it. Read together: a small fall in total cholesterol is possible, its size is a few mg/dL, and the newest pooling’s trials ran 8 to 24 weeks and counted no heart attacks or strokes, so they cannot say whether it changes anything that matters [2]. If your cholesterol needs lowering, this is not the tool.

Does hydrogen water lower blood sugar?

The trials disagree. The 24-week tablet trial reported fasting sugar and HbA1c (a three-month average of blood sugar) lower than on dummy tablets [13]. In 36 people with diabetes or prediabetes, a 2008 crossover trial found two forms of LDL and a urine oxidation marker lower; its summary gives no blood-sugar result for the group as a whole, only that 4 of the 6 with prediabetes had a normal glucose test afterwards [39]. In 50 people with type 2 diabetes, insulin resistance, the main outcome, did not differ significantly between hydrogen water and filtered water [33]. In the Chinese trial, fasting sugar fell on both waters, more on hydrogen [14]. And in the 181-person metabolic trial, HbA1c and fasting sugar did not differ significantly [15]. Small, conflicting, and mostly paid for or supplied by sellers.

Does hydrogen water help exercise recovery and energy?

This is where most of the trials are, and most of them are tiny: 8 to 24 people, often for a single session. Two poolings by the same Chinese research group cover them [59] [60]. The 2024 one combined 27 papers and 597 people [60]. Endurance, strength and maximal oxygen uptake came out not significantly different, with standardised differences from 0.04 to 0.19. Jump power was a little higher, 0.30. Perceived effort was a little lower, −0.37, and so was blood lactate, the acid that builds up in hard exercise, −0.37 [60]. That pooling mixed hydrogen water with baths, inhaled gas and a hydrogen powder: 18 of its studies were drinking trials.

The biggest single drinking study in sport we found is Japanese: 99 untrained people reported less fatigue after mild exercise, and in 60 trained people endurance and effort scores improved [61]. We read its summary only. The journal later printed a critique of it and the authors’ reply, which we did not read.

So: a small, real-looking edge in how hard exercise feels and in lactate, measured mostly in young men, and no clear edge in how far or how hard anyone could actually go. On tiredness outside sport, there are two small trials: 32 people with long Covid felt less fatigued after 14 days, in a single-blind trial [41], and 26 healthy adults had lower distress scores after four weeks, in a trial with funding from the water’s maker [43].

Does hydrogen water help the brain, ageing or skin?

The brain claims have had the longest tests, and they have not held up. Beside the 72-week Parkinson’s trial, 81 Japanese people with mild memory problems drank hydrogen water or placebo water for a year; their memory score did not differ significantly [6]. The authors reported that one subgroup, carriers of a gene variant linked to Alzheimer’s, did better: a slice, not the trial.

For ageing, one pilot: 40 Serbians aged 70 and over drank hydrogen water or plain water for six months, and of dozens of outcomes, a few were better on hydrogen, among them telomere length, the caps on chromosomes that shorten with age, at P = 0.049, just inside the line researchers use for “probably not chance” [37]. The same trial measured facial skin and found no significant difference [37]. The only other randomised drinking trial on skin we found was in 21 people with keloid scars: its summary reports pain, itch and scar scores lower after hydrogen water, without saying whether they fell more than on hydrogen-free water [47] [21].

How long does it take to feel the benefits of hydrogen water?

The trials ran from a single drink to 72 weeks. The effects people could feel, such as less fatigue or effort, were reported in short, small trials, after one session to four weeks [41] [43] [60]. The longest trials, a year in memory problems and 72 weeks in Parkinson’s, found no significant difference on their main outcome [6] [54]. None of these trials can tell you how long your own body would take to notice anything, or whether it would.

Can I make hydrogen water at home? Tablets, bottles and machines

Yes, and the trials used all of these: magnesium tablets, magnesium sticks, electrolysis machines, portable generator bottles and pressurised bottles [22] [34] [15] [27] [28]. What you cannot easily do at home is check what you made. The 2016 Japanese test found some generators making less than their manuals said, and cups of generator water losing about half their hydrogen in an hour [4]. Drink it straight away, if you drink it.

And fizz is not proof. The dummy tablets in the trials fizzed too, on purpose: in the fatty-liver trial they held magnesium carbonate, citric acid and sodium bicarbonate, which give off carbon dioxide [16]. That is also what baking soda does with an acid. Bubbles tell you a gas came out. They do not tell you it was hydrogen.

Is hydrogen water safe?

In the trials, mostly yes. In the Covid-19 trial, side effects were reported by 27% on hydrogen and 26.2% on the dummy [22]. There were two warning signs. In the Tibetan mountain-sickness trial, side effects came to 50% on hydrogen water against 37% on placebo, dizziness the most common [17]. And in a Czech test in 24 healthy adults, drinking 43 fl oz (1.26 L) in 15 minutes raised eye pressure on both waters, by amounts not significantly different, but more people had large individual rises on hydrogen water, 58% against 25% [45]. The authors suggest people with glaucoma be studied before drawing a conclusion.

In the US, the Food and Drug Administration has a GRAS file on hydrogen gas: “generally recognized as safe”. A beverage company notified the agency in 2014 that hydrogen was safe in drinking water, flavoured drinks and sodas “at a level up to 2.14% by volume”, and the FDA replied that it had no questions [62]. That is a judgement about safety at that use. It says nothing about health benefits. Japan, as above, has acted against health claims [9].

Who these studies were done on

Mostly adults in Japan, China and Serbia, many with a diagnosis: metabolic syndrome, fatty liver, diabetes or prediabetes, high cholesterol, Parkinson’s, Covid-19, mountain sickness. The exercise trials were mostly young men, many of them athletes. Three trials outside sport were in women only, with premenstrual syndrome, panic disorder and overweight [27] [44] [51]. The only randomised drinking trial in children we found was in sport: 38 girls of about 12 to 14 at a Chinese football school were split at random to drink hydrogen water or their usual water for two months [63]. It reports a damage marker and inflammation markers lower on hydrogen water than on ordinary water. But the groups were unequal from the start, 28 against 10, with the hydrogen group younger and newer to training, and the paper describes no blinding [63]. Its results also carry inconsistencies: the control group’s antioxidant capacity at four weeks is 1.11 in one sentence and 1.17 in the next, and its starting MDA and its starting IL-1, an inflammation signal, are printed with the identical figure, 24.77 ± 7.32 [63]. A trial in 60 overweight young people aged 11 to 18, registered by a Czech university in 2025, finished its main data collection in May 2026 and had posted no results when we looked [64].

So read yourself against them. If you are healthy and drink a bottle a day, the closest trials are the two Korean ones, both at 51 fl oz (1.5 L) a day: in the four-week one the oxidation markers did not differ significantly from plain water’s [11], and in the eight-week one a single oxidation marker ended lower, in a group that had started lower [12]. If you have metabolic syndrome, the biggest trial in people like you found no significant difference [15]. And whichever trial you find yourself in, the dose you drink is probably different: the newest pooling notes that the hydrogen people actually took in may have varied with how the water was made and stored and how faithfully they drank it [2].

Water itself, as it happens, has its own verdicts here: how much you need, whether it lowers blood pressure, whether you need electrolytes and whether coconut water hydrates better. And for a water sold on its chemistry, see what we found about the alkaline claims made for lemon water.

If your gut already makes hydrogen, how could a bottle matter?

This section is the desk’s own reasoning, and it is labelled as such. Your gut bacteria make hydrogen every day when they ferment what you eat; two of the trial papers say as much, one of them that the gut makes more than their high-hydrogen water delivered [46] [40]. And the bigger tests of hydrogen water have found little that holds up. Here are three ways to square that, with the evidence for each.

Answer one: the arithmetic. A litre of water saturated with hydrogen holds about 0.8 millimoles of it, about 19 mL as a gas at room temperature. In 1992, ten healthy people in a sealed room on a diet with no starch or fibre still let out about 35 mL of hydrogen a day, and more after a fermentable sugar [65]. So a litre of fully saturated hydrogen water carries roughly half what those people let out on their quietest day. The 24-week tablet trial gave more, over 5.5 millimoles a day [13], about 130 mL: more than that quiet day, less than came out after the two larger doses of the sugar. That is arithmetic, not a measurement, from one small 1992 study read as a summary.

Answer two: the spike. A drink gives a sharp, short rise in hydrogen in the blood, peaking in 5 to 15 minutes and back to normal within about an hour, as the fatty-liver trial’s authors note [16]. The same authors suggest hydrogen may work as a mild stress that sets off the body’s own defences, which they call a hormetic effect, and offered that to explain the oxidation marker that rose on it [16]. On that view a small, brief dose could matter where the gut’s steady supply does not. That is their hypothesis. No trial we read was designed to test it, and we mark it as untested.

Answer three: the size pattern. The positive results cluster in small trials, and the three biggest found no significant difference on their main outcome [22] [15] [54]. The Parkinson’s result shrank from significant in 17 patients to not significant in 178 [53] [54]. That is an observation from our tally, not a statistical test, and we mark it as one.

Put the three together and here is what we think is true, stated plainly so you can disagree with it: hydrogen water is ordinary water carrying a small, brief dose of a gas your gut already makes, and the bigger the trial, the less of a difference it has shown.

What we could not find, and would like to: a large trial, of a year or more, in healthy adults or people with metabolic syndrome, paid for by someone with nothing to sell, using a dose a shop sells, with the hydrogen measured in the cup as drunk, and inflammation markers and real outcomes as its main measures. If it exists, the corrections line on this site is open.

Where “hydrogen water fights free radicals” came from

The research behind it is real, and it was about gas. The 2007 rat study’s title called hydrogen a “therapeutic antioxidant” that works “selectively” [10]. In Japan, sellers’ pages promised that hydrogen water would disarm “bad active oxygen”: that is what the 2016 test and the 2021 orders both found [4] [9]. We did not trace who first sold a drink on the 2007 finding.

Today the claim lives in search. Ask Google about hydrogen water benefits and its AI answer calls hydrogen “a selective antioxidant”, says studies suggest it “may lower inflammatory markers”, and cites, beside two reviews, a neurology clinic’s page that says studies “have proven it may be helpful”, and a water-treatment dealer’s blog [1]. The short videos in the same results include a wellness influencer’s post whose web address says hydrogen water “has over 1400 studies”. And the product is a bottle: on the day we pulled the data, a hydrogen-water bottle brand was among Google’s fast-rising searches [1].

None of this is aimed at anyone who has bought a bottle. The research sounds good because some of it is good science, about something else. It is the leap from a rat breathing gas to a reader drinking water that the evidence has not made.

Is hydrogen water a hoax?

Not in the sense that there is nothing in it: fresh hydrogen water does carry hydrogen, and some small trials found measurable shifts. A 2024 systematic review titled “Extra Healthy or a Hoax?”, which Google’s answer cites, called the early results encouraging and asked for bigger, more rigorous trials [66]. The biggest trial on this page, in Covid-19, was published later that year, and found no significant difference on its main outcome [22]. Where it does look like a hoax is the shelf: products with less hydrogen than the label, two with none, and health claims a regulator found no reasonable basis for [4] [9].

What this is rated, and what the rating covers

Preliminary — for the claim that hydrogen water reduces inflammation and oxidative stress, as it circulates.

It is rated Preliminary because the evidence in its favour is small, early and conflicting. Some small trials found inflammation or oxidation markers better on hydrogen water [13] [11]; others found no significant difference [15] [14]; in one, its oxidation markers pointed different ways [12]; in a preprint, MDA and SOD were not significantly different and one of four oxidised fats, measured only at the end, was lower on hydrogen [31]; and two found an oxidation marker higher [16] [17], one of them with antioxidant capacity higher too. The only pooling of these markers in people alone, in exercise, could not tell hydrogen from a dummy on oxidised compounds and found antioxidant capacity slightly higher [19]. In 22 of the 41 trials in our table a seller paid, supplied what was drunk or employed an author. We stop short of Unsupported because the claim has not had a large, fair test: every trial of more than 100 people that we found was built around another outcome, such as Covid-19, waist size or a symptom score, and the biggest to measure these markers at all, 181 people, measured them on the side and found no significant difference [15]. The trials that made the markers their main outcome were smaller, and their results point in different directions [17] [12].

Each part, rated alone, in words. That it improves exercise recovery, in effort and lactate: Preliminary, on small, short trials, mostly in young men, with endurance and strength not significantly different [60]. That it boosts energy or eases fatigue: Preliminary, on two small trials [41] [43]. That it lowers cholesterol: Preliminary, a fall of a few mg/dL in two of three poolings and not in the third [2] [56]. That it lowers blood sugar: Preliminary, on small, conflicting trials [13] [33]. That it slows ageing: Preliminary, on one 40-person pilot [37]. That it improves your skin: Preliminary, on two small trials: the same pilot found facial skin not significantly different [37], and in the 21-person keloid trial pain, itch and scar scores were lower after hydrogen water, though its summary does not compare them with the other group [47]. That it lifts mood: Preliminary, on one 26-person crossover [43] and a 25-woman trial in panic disorder that was not significantly better than placebo [44].

That it helps Parkinson’s disease: Unsupported, of the tested kind, on the 178-patient trial [54]. That it slows memory decline: Unsupported, of the tested kind, on the year-long trial [6]. That it helps you recover from Covid-19: Unsupported, of the tested kind, on the 700-person trial in mild or moderate illness [22]; the small long-Covid trial, on fatigue, is rated with energy above.

What is not rated here: inhaled hydrogen and hydrogen baths, which are different treatments; alkaline water for its alkalinity; and the frame above, which is this desk’s reasoning from the evidence rather than a result the evidence delivered. It is marked as ours so that you can weigh it as ours.

This is journalism, not medical advice. If you are thinking of using hydrogen water for a condition, talk to a clinician who knows your history. How we read a study, and what each tier means, is set out here.

Sources
[1] Search data from a paid keyword database: the monthly US search volume for “hydrogen water benefits” and “does hydrogen water work”, pulled 23 October 2026, with each month of the past year; Google’s results, People Also Ask questions, related searches and AI answer for “hydrogen water benefits”, pulled the same day; and Google Trends rising searches pulled the same day, among them a hydrogen-water bottle brand. Three of the pages the AI answer cites, read on 23 October 2026: a neurology clinic’s page on “molecular hydrogen therapy”, a water-treatment dealer’s blog post (13 May 2024) and a cancer centre’s blog post (29 January 2026). Kept with this page’s records.
[2] Ye H, Fang J, Safargar M, et al. The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome 2026;18:114. Read in full on PubMed Central, with its forest plots from PubMed Central’s open-data copy. Zhejiang provincial grant; no competing interests. doi:10.1186/s13098-026-02124-0
[3] Wu F, Ma J, Xue J, et al. Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: a randomized placebo-controlled trial. Heliyon 2024;10(16):e36401. Read in full on PubMed Central. National Natural Science Foundation of China and provincial grants; the water provided by a hydrogen-water company; no competing interests. doi:10.1016/j.heliyon.2024.e36401
[4] National Consumer Affairs Center of Japan. 容器入り及び生成器で作る、飲む「水素水」 (Drinking “hydrogen water”, packaged or made with generators: there is no official definition, and dissolved hydrogen varies). Press release, 15 December 2016, updated 20 January 2017. Its summary page read in full, in Japanese, on the centre’s site on 23 October 2026; the full report (PDF) was not read. Ten packaged brands and nine generators tested. No DOI.
[5] LeBaron TW, Larson AJ, Ohta S, et al. Acute supplementation with molecular hydrogen benefits submaximal exercise indices: randomized, double-blinded, placebo-controlled crossover pilot study. Journal of Lifestyle Medicine 2019;9(1):36–43. Read in full on PubMed Central, for its measurement of tablet water; tablets donated by the tablet maker. doi:10.15280/jlm.2019.9.1.36
[6] Nishimaki K, Asada T, Ohsawa I, et al. Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Current Alzheimer Research 2018;15(5):482–492. Read in full on PubMed Central. Japan Society for the Promotion of Science grants; both waters from a hydrogen-water company, which the senior author advised from 2005 to 2008. doi:10.2174/1567205014666171106145017
[7] Kuzmanovic J, Todorovic N, Ranisavljev M, et al. The effects of drinking hydrogen-rich water for six weeks on exercise-related biomarkers in exercise-naïve men and women over 50 years following resistance training program: a randomized controlled pilot trial. Research in Sports Medicine 2025;33(6):711–721. Read as its published abstract, with its author affiliations; its funding statement was not read. doi:10.1080/15438627.2025.2521474
[8] Tamura T, Suzuki M, Homma K, et al. Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial. eClinicalMedicine 2023;58:101907. Read in full on PubMed Central. Funded by an industrial gas company. doi:10.1016/j.eclinm.2023.101907
[9] Consumer Affairs Agency, Japan. 水素水生成器の販売・レンタルサービスの提供事業者4社に対する景品表示法に基づく措置命令について (Orders under the Act against Unjustifiable Premiums and Misleading Representations against four companies selling or renting hydrogen-water generators). News release with the orders, 30 March 2021. The release and the first orders read in Japanese in the Internet Archive’s copy (captured 10 February 2025), as the agency’s own link no longer opens. No DOI.
[10] Ohsawa I, Ishikawa M, Takahashi K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine 2007;13(6):688–694. Read as its published abstract; its funding statement was not read. doi:10.1038/nm1577
[11] Sim M, Kim CS, Shon WJ, et al. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. Scientific Reports 2020;10(1):12130. Read in full on PubMed Central. Supported by a water-purifier company, which also made the plain water, and by Korean public grants; the hydrogen water was a commercial brand; no competing interests. doi:10.1038/s41598-020-68930-2
[12] Choi YA, Lee DH, Cho DY, Lee YJ. Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace—Drinking Electrolyzed-Reduced Water (OASIS-ERW): a randomized, double-blind, placebo-controlled trial. Antioxidants 2020;9(7):564. Read in full on PubMed Central. Supported by a health foundation; the machines that made both waters were installed by their maker, whose engineer also attached the coloured photos that matched each machine to its group, and the paper does not say whether the machines were bought, lent or given; the authors declare no conflicts. It names two antioxidant enzymes, SOD and catalase, among its main outcomes and reports neither, in the paper or in its supplement. doi:10.3390/antiox9070564
[13] LeBaron TW, Singh RB, Fatima G, et al. The effects of 24-week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: a randomized controlled trial. Diabetes, Metabolic Syndrome and Obesity 2020;13:889–896. Read in full on PubMed Central. Partly supported by Slovak public grants and by the tablet maker, which donated the tablets; the lead author reports speaking and consultancy fees regarding molecular hydrogen. doi:10.2147/DMSO.S240122
[14] Liang B, Shi L, Du D, et al. Hydrogen-rich water ameliorates metabolic disorder via modifying gut microbiota in impaired fasting glucose patients: a randomized controlled study. Antioxidants 2023;12(6):1245. Read in full on PubMed Central. Chinese national and provincial grants; both waters made by a hydrogen-water company; no conflicts. doi:10.3390/antiox12061245
[15] Moribe R, Minami M, Hirota R, et al. Health effects of electrolyzed hydrogen water for the metabolic syndrome and pre-metabolic syndrome: a 3-month randomized controlled trial and subsequent analyses. Antioxidants 2024;13(2):145. Read in full on PubMed Central. Funded by the maker of the machines (grant 36-78); one author works for it. doi:10.3390/antiox13020145
[16] Kura B, Szantova M, LeBaron TW, et al. Biological effects of hydrogen water on subjects with NAFLD: a randomized, placebo-controlled trial. Antioxidants 2022;11(10):1935. Read in full on PubMed Central. Slovak public grants and the tablet maker, which supplied the hydrogen and dummy tablets; no conflicts declared. doi:10.3390/antiox11101935
[17] Zhang F, Zhong Y, Li Q, et al. Does hydrogen-rich water reduce oxidative stress in patients with chronic mountain sickness? A randomized, blinded, controlled trial. High Altitude Medicine & Biology 2026;27(3):133–142. Read as its published abstract, with its disclosure statement (no competing interests); its funding statement was not read. doi:10.1177/15578682251401137
[18] Zhang Q, Zhang F, Zhong Y, et al. Hydrogen-rich water supplementation attenuates oxidative stress and inflammation in chronic high-altitude disease patients: a double-blind randomized placebo-controlled study. Food Research International 2025;219:117118. Read as its published abstract, with its declaration (no competing interests); its funding statement was not read. doi:10.1016/j.foodres.2025.117118
[19] Li Y, Bing R, Liu M, et al. Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis. Frontiers in Nutrition 2024;11:1328705. Read in full on PubMed Central. Chinese national research grant; no conflicts. doi:10.3389/fnut.2024.1328705
[20] Bai Y, Wang C, Jiang H, et al. Effects of hydrogen rich water and pure water on periodontal inflammatory factor level, oxidative stress level and oral flora: a systematic review and meta-analysis. Annals of Translational Medicine 2022;10(20):1120. Read in full on PubMed Central: 17 studies and 304 subjects; by its own table and reference list, 4 of the 17 were in people, 8 in rats or mice and 5 in cells or bacteria in the lab. No funding; no conflicts declared. doi:10.21037/atm-22-4422
[21] Our searches, 23 October 2026: PubMed by title and abstract in two wordings for randomised trials of drinking hydrogen water or taking hydrogen tablets (89 and 439 records, every relevant title read), a title search (190 records), searches for reviews and poolings (101 and 18 records) and for skin (31 and 11 records); Europe PMC for later accounts of the Parkinson’s trial; ClinicalTrials.gov (27 registered studies under “hydrogen-rich water”, none larger than the Covid-19 trial and none with results posted); and two ordinary web searches, first pages read. Run again the same day after an independent review: PubMed in further wordings for trials in children (31 and 203 records), for poolings (28), for trials of any kind (190) and for electrolysed, alkaline and “reduced” waters (52 and 69); Europe PMC’s full-text search for poolings (24); Crossref and Research Square for preprints; ClinicalTrials.gov under five wordings; and three more web searches. After a second review: PubMed for drinking trials on skin in two more wordings (89 and 5 records), ClinicalTrials.gov under five skin wordings, and one more web search. Japan’s jRCT and UMIN registries, China’s ChiCTR and the WHO’s trial portal could not be searched from here: a failed connection, an unknown address, a page that needs a script, a server error. The record is kept with this page.
[22] Gaboreau Y, Milovančev A, Rolland C, et al. Molecular hydrogen for outpatients with COVID-19 (Hydro-COVID): a phase 3 randomised, triple-blinded, pragmatic, placebo-controlled, multicentre trial. Journal of Clinical Medicine 2024;13(15):4308. Read in full on PubMed Central. Funded by the maker of the tablets used, a public research laboratory, a university foundation, a home-health association, an insurer and a dermatology association; one author works for a home-health company; the authors declare no conflicts. doi:10.3390/jcm13154308
[23] Yoritaka A, Ohtsuka C, Maeda T, et al. Randomized, double-blind, multicenter trial of hydrogen water for Parkinson’s disease. Movement Disorders 2018;33(9):1505–1507. Not read: a letter behind a paywall; the Internet Archive holds only its landing page, which gives the funder (the Japan Society for the Promotion of Science) and “Nothing to report” on conflicts. Its result is taken from [54] and [55]. doi:10.1002/mds.27472
[24] Yang Q, Ji G, Pan R, et al. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Molecular and Clinical Oncology 2017;7(5):891–896. Read in full on PubMed Central’s page, whose acknowledgements give its funder: the Tai’an city science and technology fund (grant 2015NS2098). We found no conflict statement in it. doi:10.3892/mco.2017.1409
[25] Yin Y, Wang J, Lian F, et al. Hydrogen-rich water combined with traditional Chinese medicine compound in the treatment of kidney stones: a randomized controlled prospective clinical trial. Medical Gas Research 2027;17(1):63–69. Read in full on PubMed Central. Chinese public grants; the generators provided by a nanobubble technology company; no conflicts declared. PubMed 42734448; PubMed Central PMC13667379. The DOI the paper prints did not resolve when we checked on 23 October 2026.
[26] Franceschelli S, Gatta DMP, Pesce M, et al. Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: a new biological vision. Journal of Cellular and Molecular Medicine 2018;22(5):2750–2759. Read in full on PubMed Central. Italian Ministry for the University and Research. doi:10.1111/jcmm.13569
[27] Aker MN, Gönenç İM, Çalişici D, et al. The effect of hydrogen-rich water consumption on premenstrual symptoms and quality of life: a randomized controlled trial. BMC Women’s Health 2024;24(1):197. Read in full on PubMed Central. Ankara University grant; no competing interests. doi:10.1186/s12905-024-03029-8
[28] Ishibashi T, Kawamoto K, Matsuno K, et al. Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: a randomized controlled trial. PLoS ONE 2020;15(5):e0233484. Read in full on PubMed Central. No specific funding; no competing interests declared; two authors list a hydrogen clinic among their affiliations. doi:10.1371/journal.pone.0233484
[29] Song G, Lin Q, Zhao H, et al. Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized, and placebo-controlled trial. Journal of Clinical Endocrinology & Metabolism 2015;100(7):2724–2733. Read as its published abstract; its funding statement was not read. doi:10.1210/jc.2015-1321
[30] Tanaka Y, Saihara Y, Izumotani K, et al. Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms. Medical Gas Research 2018;8(4):160–166. Read in full on PubMed Central. The corresponding author is a salaried employee of the appliance maker, and a second author was. doi:10.4103/2045-9912.248267
[31] Gu Q, Liu B, Xue J, et al. Effects of drinking hydrogen-rich water in men at risk of peripheral arterial disease: a randomized placebo-controlled trial. Research Square, posted 6 January 2021. A preprint: it has not been peer reviewed, and we found no journal version of it. Read in full on Research Square. Chinese national and provincial grants and a university programme; the hydrogen water bought from a hydrogen-water company; no conflicts declared. Its summary says total cholesterol was “significantly reduced compared to the placebo group”; its own table shows it rose on placebo water and not significantly on hydrogen water. doi:10.21203/rs.3.rs-136097/v1
[32] Ostojic SM, Stojanovic MD. Hydrogen-rich water affected blood alkalinity in physically active men. Research in Sports Medicine 2014;22(1):49–60. Read as its published abstract; its funding statement was not read. doi:10.1080/15438627.2013.852092
[33] Ogawa S, Ohsaki Y, Shimizu M, et al. Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial. Diabetology International 2022;13(1):209–219. Read in full on PubMed Central’s page. Funded by the machine maker; two authors its employees. doi:10.1007/s13340-021-00524-3
[34] Kang KM, Kang YN, Choi IB, et al. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research 2011;1(1):11. Read in full on PubMed Central. Supported by a Japanese research foundation’s grant. doi:10.1186/2045-9912-1-11
[35] Stolecka-Warzecha A, Zając T, Gandyk M, et al. Redox water consumption attenuates exercise-induced inflammation and oxidative stress in physically active adults: a randomized controlled trial. Nutrients 2026;18(4):694. Read in full on PubMed Central. Funded, with its publication fee, by the company whose generator made the water; the authors declare no conflicts. doi:10.3390/nu18040694
[36] Si Y, Tian H, Dong B, et al. Effects of hydrogen as adjuvant treatment for unstable angina. Experimental Biology and Medicine 2021;246(18):1981–1989. Read in full on PubMed Central’s page. Chinese public grants; no conflicts declared. doi:10.1177/15353702211009138
[37] Zanini D, Todorovic N, Korovljev D, et al. The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: a randomized controlled pilot trial. Experimental Gerontology 2021;155:111574. Read as its published abstract; its funding statement was not read. doi:10.1016/j.exger.2021.111574
[38] Todorovic N, Baltic S, Nedeljkovic D, et al. The effects of 8-week hydrogen-rich water consumption on appetite, body composition, sleep quality, and circulating glucagon-like peptide-1 in obese men and women (HYDRAPPET): a randomized controlled trial. Medicina 2025;61(7):1299. Read in full on PubMed Central. Partly funded by a Serbian provincial secretariat and a hydrogen-product company, which supplied the drinks and employs one author. doi:10.3390/medicina61071299
[39] Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research 2008;28(3):137–143. Read as its published abstract; its funding statement was not read. doi:10.1016/j.nutres.2008.01.008
[40] Sakai T, Sato B, Hara K, et al. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vascular Health and Risk Management 2014;10:591–597. Read in full on PubMed Central. No conflicts declared; one author’s affiliation is a company that makes hydrogen generators; the water was a hydrogen-water company’s product. doi:10.2147/VHRM.S68844
[41] Tan Y, Xie Y, Dong G, et al. The effect of 14-day consumption of hydrogen-rich water alleviates fatigue but does not ameliorate dyspnea in long-COVID patients: a pilot, single-blind, and randomized, controlled trial. Nutrients 2024;16(10):1529. Read in full on PubMed Central. No external funding; no conflicts. doi:10.3390/nu16101529
[42] Matsumoto S, Ueda T, Kakizaki H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology 2013;81(2):226–230. Read in full as the authors’ accepted manuscript in their university’s repository, not the journal’s version. Funded by a public-health research foundation; the paper says the hydrogen water and the placebo water were both obtained from a drug company, without saying who made them or whether they were bought or given; we found no conflict statement in it. doi:10.1016/j.urology.2012.10.026
[43] Mizuno K, Sasaki AT, Ebisu K, et al. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Medical Gas Research 2017;7(4):247–255. Read in full on PubMed Central. One author received funding for the study from the company that made both waters. doi:10.4103/2045-9912.222448
[44] Fernández-Serrano AB, Moya-Faz FJ, Giner Alegría CA, et al. Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial. Health Psychology Research 2022;10(3):35468. Read in full on PubMed Central’s page: 25 women, 12 on hydrogen water. No specific grant (a university doctoral programme supported it); the hydrogen-water generator came from a company whose technical staff installed it and whose manager is an author, and the authors thank that company for supporting the project; they declare no competing interests. doi:10.52965/001c.35468
[45] Najmanová E, Manethová H, Botek M, Pluháček F. Effect of acute hydrogen-rich water intake on intraocular pressure in healthy subjects. Česká a slovenská oftalmologie 2023;79(4):180–184. Read as its published abstract; its funding statement was not read. doi:10.31348/2023/23
[46] Ito M, Ibi T, Sahashi K, et al. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research 2011;1(1):24. Read in full on PubMed Central. Japanese government grants; both the hydrogen water and the placebo water bought from a hydrogen-water company; no competing interests. doi:10.1186/2045-9912-1-24
[47] Kuang X, Liang Z, Shan M, et al. Exploratory evaluation of hydrogen-rich water therapy for keloid management: a double-blinded randomized pilot trial. Aesthetic Plastic Surgery 2026;50(9):3448–3459. Read as its published abstract, with PubMed’s grant list and its conflict statement; its funding statement and its results tables were not read. Its summary reports changes after treatment in the hydrogen group and gives no comparison with the control group. The journal later printed a letter commenting on it (2026;50:3460–3461), which we did not read. doi:10.1007/s00266-025-05512-5
[48] Tanaka Y, Kiuchi M, Higashimura Y, et al. The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial. Medical Gas Research 2021;11(4):138–144. Read in full on PubMed Central. The first author’s affiliation is the appliance maker. doi:10.4103/2045-9912.318858
[49] Todorovic N, Zanini D, Stajer V, et al. Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers. Food Science & Nutrition 2021;9(9):5139–5145. Read in full on PubMed Central. Serbian public funds and the tablet maker, which provided the tablets; no conflicts declared. doi:10.1002/fsn3.2480
[50] Korovljev D, Stajer V, Ostojic J, et al. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clinics and Research in Hepatology and Gastroenterology 2019;43(6):688–693. Read as its published abstract; its funding statement was not read. doi:10.1016/j.clinre.2019.03.008
[51] Korovljev D, Trivic T, Drid P, Ostojic SM. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Irish Journal of Medical Science 2018;187(1):85–89. Read as its published abstract and PubMed’s grant list, which includes Serbian public grants and one from a US company; its funding statement was not read. doi:10.1007/s11845-017-1638-4
[52] Yoritaka A, Abe T, Ohtsuka C, et al. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurology 2016;16:66. Read in full on PubMed Central. Japan Society for the Promotion of Science grant; the hydrogen water and placebo water supplied by two companies. doi:10.1186/s12883-016-0589-0
[53] Yoritaka A, Takanashi M, Hirayama M, et al. Pilot study of H2 therapy in Parkinson’s disease: a randomized double-blind placebo-controlled trial. Movement Disorders 2013;28(6):836–839. Read as its published abstract; its funding statement was not read. doi:10.1002/mds.25375
[54] Yoritaka A, Kobayashi Y, Hayashi T, et al. Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study. Neurological Sciences 2021;42(11):4767–4770. Read in full on PubMed Central; its introduction describes the 72-week drinking trial’s result. doi:10.1007/s10072-021-05489-4
[55] Wang F, Zhang G, Zhai Q. Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases. Frontiers in Neuroscience 2025;19:1576773. A review, read in full on PubMed Central, for its description of the 72-week trial. doi:10.3389/fnins.2025.1576773
[56] Jamialahmadi H, Khalili-Tanha G, Rezaei-Tavirani M, Nazari E. The effects of hydrogen-rich water on blood lipid profiles in metabolic disorders clinical trials: a systematic review and meta-analysis. International Journal of Endocrinology and Metabolism 2024;22(3):e148600. Read in full on PubMed Central. University grant; no competing interests. doi:10.5812/ijem-148600
[57] Todorovic N, Fernández-Landa J, Santibañez A, et al. The effects of hydrogen-rich water on blood lipid profiles in clinical populations: a systematic review and meta-analysis. Pharmaceuticals 2023;16(2):142. Read in full on PubMed Central. Serbian provincial grant; no conflicts declared. doi:10.3390/ph16020142
[58] Sumbalová Z, Kucharská J, Rausová Z, et al. The effect of adjuvant therapy with molecular hydrogen on endogenous coenzyme Q10 levels and platelet mitochondrial bioenergetics in patients with non-alcoholic fatty liver disease. International Journal of Molecular Sciences 2023;24(15):12477. Read in full on PubMed Central: the same 30 patients as [16]. Slovak public grants and the tablet maker, which also donated the hydrogen and dummy tablets; no conflicts declared. doi:10.3390/ijms241512477
[59] Zhou K, Liu M, Wang Y, et al. Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: a systematic review and meta-analysis. Frontiers in Nutrition 2023;10:1094767. Read in full on PubMed Central. Chinese national research grant; no conflicts. doi:10.3389/fnut.2023.1094767
[60] Zhou K, Shang Z, Yuan C, et al. Can molecular hydrogen supplementation enhance physical performance in healthy adults? A systematic review and meta-analysis. Frontiers in Nutrition 2024;11:1387657. Read in full on PubMed Central. Chinese national research grant; no conflicts. doi:10.3389/fnut.2024.1387657
[61] Mikami T, Tano K, Lee H, et al. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Canadian Journal of Physiology and Pharmacology 2019;97(9):857–862. Read as its published abstract and author affiliations, one of them a hydrogen-health company; its funding statement was not read. The journal later printed a critique and the authors’ reply (2021;99(10):1114–1117), neither of which we read. doi:10.1139/cjpp-2019-0059
[62] US Food and Drug Administration. GRAS Notice Inventory, GRN No. 520: Hydrogen gas. Intended use: “as an ingredient in drinking water, flavored beverages, and soda drinks at a level up to 2.14% by volume”. Notifier: a beverage company. Closed 28 November 2014: “FDA has no questions”. The inventory entry read on the FDA’s site on 23 October 2026; the notice itself (PDF) was not read. No DOI.
[63] Sha JB, Zhang SS, Lu YM, et al. Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China. Medical Gas Research 2018;8(4):135–143. Read in full on PubMed Central. Chinese national research grants; no conflicts declared; two of its 15 authors give a health-management company as their affiliation and, by the paper’s author contributions, collected and analysed the data. The paper does not say where its hydrogen water came from or how much hydrogen it held. Its results give the control group’s antioxidant capacity at four weeks as 1.11 and then as 1.17, and the same figure, 24.77 ± 7.32, for that group’s starting MDA and its starting IL-1. doi:10.4103/2045-9912.248263
[64] ClinicalTrials.gov NCT06961110: a randomised, double-blind trial of hydrogen-rich water or drinking water, 1.5 L a day, during a weight-loss stay for overweight and obese teenagers, sponsored by a Czech university; 60 enrolled, aged 11 to 18. The registry record read on 23 October 2026: first posted 7 May 2025, main data collection completed 29 May 2026, no results posted. No DOI.
[65] Christl SU, Murgatroyd PR, Gibson GR, Cummings JH. Production, metabolism, and excretion of hydrogen in the large intestine. Gastroenterology 1992;102(4 Pt 1):1269–1277. Ten healthy people in a whole-body calorimeter. Read as its published abstract; its funding statement was not read. PubMed’s record carries no DOI.
[66] Dhillon G, Buddhavarapu V, Grewal H, et al. Hydrogen water: extra healthy or a hoax? A systematic review. International Journal of Molecular Sciences 2024;25(2):973. Read in full on PubMed Central. No external funding; no conflicts. doi:10.3390/ijms25020973