The Study Behind Clove Coffee’s Blood-Sugar Claim: 13 People, No Comparison Group, Maker-Paid

“Crush 1 clove.” “Add it to your coffee and wait 2 minutes.” “Drink!” That recipe is from the description of “1 CLOVE in Your Coffee Every Morning (Here’s What Happens)”, posted on 16 September 2026 by a chiropractor’s health-video channel whose creator directs a supplement company; every description on the channel advertises its products. The video had 6,176,664 views when we read it on 10 October 2026 [1].

The description says clove coffee “supports digestion and healthy blood sugar”. It says eugenol, the main ingredient of clove oil, “can be beneficial against H. pylori because it survives stomach acid”, and it lists “Fights ulcers” among the benefits that, it says, “Research has shown” [1]. It gives three papers as its data: a trial of a clove mouthwash in intensive-care patients on ventilators [2], a test-tube study of eugenol against H. pylori [3], and a 30-day study of a clove extract and blood sugar [4].

Plenty of people are asking. In the United States, “clove benefits” is searched about 49,500 times a month, “clove coffee” about 2,900 times and “cloves in coffee benefits” about 140 times a month (from a paid keyword database, pulled 10 October 2026) [5]. Ask Google about clove benefits and its AI answer says clove extracts fight “stomach pathogens like H. pylori”; the first page it cites for that line is this video [5].

Nobody has tested a clove in coffee. We searched medical databases and trial registries and found no trial of it, for blood sugar or anything else [6]. The nearest is a Saudi trial of coffee brewed with cardamom, cloves and saffron, which measured blood pressure, not blood sugar [7].

The blood-sugar study the video lists had 13 people and nobody to compare them with. They took a capsule of a clove extract that its maker calls “de-flavoured”, and the maker paid for the study [4] [8]. A larger trial of the same extract, in 2022, did have a comparison group and reported falls in blood sugar; the maker’s staff are among its authors too, and we could read only its summary and charts, which do not all agree with each other [37].

The stomach claims come from dishes and animals. Eugenol stops H. pylori in a flask [3]. The one trial we found of a clove compound in people with the infection cleared nobody’s infection [9].

What is in a clove?

A clove is a dried flower bud, picked before it opens [10]. Most of its smell and bite is in its oil [11], and most of the oil is eugenol: about three quarters of it, in clove-bud oil analysed for Europe’s food safety authority [12]. Measured in cloves as sold, eugenol comes to about 94 to 147 mg in every gram [13]. A teaspoon of ground cloves weighs 2.1 g [14], so it holds roughly 200 to 310 mg of eugenol, by our arithmetic.

And one clove? We could not find a published measurement of what a single dried clove weighs [6]. So the arithmetic on this page works in grams and teaspoons. A kitchen scale will tell you what yours weigh.

Do cloves lower blood sugar?

Here is the study the video lists. In September and October 2014, researchers in Kerala, India, gave 13 volunteers aged 25 to 35, ten men and three women, a 250 mg capsule after lunch every day for 30 days [4] [15]. Seven started with blood sugar of 100 mg/dL or below before lunch. Six started between 101 and 125, a group the paper calls prediabetic: above normal, below the line for diabetes [4]. (mg/dL, milligrams per deciliter, is the scale American blood-sugar meters use.)

Two hours after lunch, their blood sugar fell. In the first group it went from 125.4 to 98.4 mg/dL by day 30; in the second, from 148.3 to 108 [4]. Before lunch it fell only in the second group, from 114.2 to 100.5 [4]. Blood sugar was measured with a finger-prick meter [4].

Now the part the result depends on. Nobody was given a dummy capsule. Everyone knew what they were taking, and so did the researchers: what is called an open-label study, and in the paper’s own words “no investigators were blinded” [4]. With nobody to compare against, a fall over 30 days could come from the capsule. It could also come from people eating a little differently once they knew their sugar was being watched, or from regression to the mean: numbers picked out because they were high tend to come back down on the next reading by themselves. The study cannot tell those apart. That is a limit of its design, and the two other explanations are ours, not findings.

Who paid? The company that makes the extract, an Indian flavor company, under a development program for its spice ingredients. Two of the six authors worked for that company, and two more worked for a US supplement company that, in the paper’s words, “sells finished products containing” the extract [4]. By the paper’s own account, two of the maker’s employees designed the study, the two college authors ran the experiments and collected the data, and one of the maker’s employees and the supplement company’s two analysed the data and wrote the paper [4]. Its registry entry says it was “funded by and will be conducted at” the maker’s research centre [15]. The study was entered in that registry in September 2018, almost four years after it ended [4] [15]. The entry states the study’s hypothesis as falls in blood sugar of 5 mg/dL before meals and 40 mg/dL after them; in the paper, the after-lunch falls were 27.00 in the normal group and 40.33 in the raised group [4] [15]. Registering a trial before it starts is how researchers show they did not pick what to report after seeing the results; registering it afterwards cannot show that.

And what was in the capsule? Not a clove. It was a powder made by soaking dried clove buds in water and alcohol, drying what dissolved, and standardising it to at least 30% polyphenols [4], a large family of plant compounds that, in a clove, carry its bitterness and astringency rather than its smell [11]. The maker’s own papers call it “de-flavoured” [8] and say it was made “without the issues of its characteristic pungency and aroma” [16]. Eugenol is in it, in an amount none of the maker’s papers we read states [11] [4].

So the study the video offers for a clove’s eugenol tested an extract its maker calls de-flavoured, made to taste and smell far less of clove; the maker’s safety paper describes the powder as having a “mild taste and aroma characteristic of clove” [11]. Does that mean eugenol did nothing? Nobody measured. It means this study cannot be evidence that eugenol did something.

Is there a better test of the extract? There is one, and the video does not cite it. In 2022, a team that included two of the maker’s research staff and a contract research company gave 70 adults with metabolic syndrome, a cluster of conditions that includes raised blood sugar, blood pressure and blood fats and a large waist, either 250 mg a day of the same extract or 250 mg of synthetic glutathione, an antioxidant supplement, for 84 days; 64 finished [37]. The paper calls it double-blinded: neither the participants nor the researchers were meant to know who took which. It reports that fasting and after-meal blood sugar, and HbA1c, a blood test that gives a rough three-month average of blood sugar, fell further on the extract than on glutathione [37].

Four things keep it from settling the question. First, the comparison was another supplement, not a dummy capsule, so the trial can show that the extract did better than glutathione; it cannot show how the extract compares with taking nothing. Second, on the paper’s own charts the extract group started higher, at about 6.9% HbA1c against 6.2%, and about 171 against 160 mg/dL after a meal, and numbers that start higher have further to fall [37]. On the extract, the chart has HbA1c falling to about 5.3% in 84 days [37]. Third, the charts do not agree with each other. Researchers often score insulin resistance, how much insulin the body needs to keep blood sugar down, as HOMA-IR: fasting blood sugar in mg/dL times fasting insulin, divided by 405. For the extract group at 84 days, the chart’s fasting sugar of about 93 and insulin of about 12.2 give a score of about 2.8; the chart prints about 1.2. The same sum comes within 0.05 of the chart’s other three scores. The insulin chart shows insulin rising on the extract, from about 8.9 to about 12.2, and the summary lists insulin among the measures the extract improved. And the summary says glutathione showed “no significant effect on blood glucose”, while the charts mark its falls in fasting sugar, after-meal sugar and HbA1c with P < 0.001, which researchers read as very unlikely to be chance [37]. That is our arithmetic, on values we read off the paper’s charts; its tables would show which figure is wrong, and we could not read them. Fourth, we could read only its summary, author list and charts: the paper is free to read on the publisher’s site, but the site refused our automated reading, so we have not seen its tables or its funding statement [37]. It is a trial of an extract, not of a clove.

Has anyone tested whole cloves on blood sugar?

Three times, that we found, and the third is told in two documents that do not agree on how it was run [6]. In 2006, researchers from an agricultural university and a hospital in Peshawar, Pakistan, and a US Department of Agriculture nutrition laboratory presented a meeting abstract, a one-paragraph summary given at a scientific conference [17]. Thirty-six people with type 2 diabetes took capsules holding 0, 1, 2 or 3 g of cloves a day for 30 days. With the three clove groups put together, their blood sugar fell from 225 to 150 mg/dL; “There were no significant changes in the placebo group” [17]. One to three grams is about half a teaspoon to a teaspoon and a half of ground cloves, by our arithmetic [14].

Hold it loosely. A meeting abstract is not a full paper checked by reviewers in the usual way, and this one never compares the clove groups with the dummy group directly; it says only that one changed and the other did not [17]. We found no full paper of it in the twenty years since [6]. And a 2003 cinnamon trial by three of the same four authors, which had a similar design (several doses in capsules against dummy capsules, then a break), is now under an expression of concern, a formal warning a journal attaches to a paper it has doubts about. In August 2025 its journal said independent statisticians had found differences between the groups at the start “inconsistent with proper randomization”, unclear reporting of how people were assigned, and “unusually high reported participant adherence” with nobody lost along the way, and that it could not reach the authors [18]. That concern is about the cinnamon paper, not the clove abstract. It matters here because the clove abstract reports even less than the cinnamon paper did, so it cannot answer those questions either.

The second test is Danish, and it is the only one we found of cloves on their own eaten as food [6]. For the Christmas issue of the Danish medical journal in 2021, hospital doctors gave 12 healthy adults, mostly women, aged 25 to 63, the same rice pudding on different days, plain or topped with spices, and tracked their blood sugar with a sensor worn under the skin [19]. On the clove day, 1 g went on breakfast and 3 g on lunch. Against plain pudding there was no difference in how far blood sugar rose or how high it peaked [19]. It is one meal, in healthy people, with the days in a fixed order rather than a random one, and the paper is written partly in fun: eight of the twelve said they would rather risk the complications of higher blood sugar than eat the spices on their pudding [19]. It reports no funding and no conflicts [19].

The third is told twice. The later telling is a 2014 report from a college of arts and home science in Surat, India, in a pharmacy journal that PubMed does not index [38]. It says 45 adults with diabetes and raised blood fats were split into three groups of 15: one took 4 g of powdered cloves a day in capsules, about two teaspoons by our arithmetic [14], one took turmeric, and one took capsules of roasted rice-flake flour as a dummy [38]. On cloves, it reports fasting blood sugar falling from 163.9 to 124.2 mg/dL and HbA1c from 8.1% to 7.25%, with almost no change on the rice flakes [38]. That is close to the trial this page would ask for. We cannot rely on it, for reasons printed on its own pages.

It gives the trial’s length as three months in some places and two months in others [38]. Its table of after-meal blood sugar does not subtract: the clove group went from 265.33 to 215.67 mg/dL, a fall of 49.66 by our arithmetic, and the table prints the fall as 42.47 [38]. It does not say how people were put into groups, and it states no funding, no ethics approval and no consent [38]. Its description of its 45 participants repeats, figure for figure, the description a 2012 paper by two researchers at a women’s university in Coimbatore, India, gives for a survey of 500 adults employed at an industrial firm there: the same 30.4% aged 40 to 45, the same 47% in joint families and 53% in nuclear ones, the same 45% practising yoga [38] [39]. By our arithmetic, 30.4% of 45 people is 13.7 people; no whole number of people out of 45 makes 30.4%. That 2012 paper’s own trial gave 45 of those workers with raised blood fats 2 g of cloves or turmeric a day, or capsules of powdered sugar, for three months, and measured blood fats, not blood sugar [39]. And the same two researchers have a paper listed in the April 2010 issue of an Indian nutrition journal under the 2014 report’s exact title [40]. We could not read it: the journal’s site served a bot check, and no index or archive we tried holds a copy [40].

The earlier telling is a 2008 doctoral thesis written at that Coimbatore university by the first of those two researchers and supervised by the second; the university holds it in an open repository [46]. The 2014 report’s table of blood sugar and HbA1c repeats, to the second decimal, the thesis’s rows for cloves, turmeric and the dummy capsules, and its weight and blood-fat figures for those three groups are the thesis’s too [38] [46]. That includes the after-meal fall printed as 42.47: the thesis prints the same figure, and the readings for each man in the thesis’s own appendix put the average fall at 49.67, by our arithmetic [46]. It includes the dummy group’s change in fasting blood sugar, printed in both as a rise of 0.4, where those readings give a fall of 0.53 [46]. But the thesis describes the trial differently. Its 75 men all worked for one government-run company in Coimbatore; the 2014 report says its adults lived in Surat. They took 2 g of cloves a day, not 4 g. The dummy capsules held roasted Bengal gram flour, a chickpea flour, not rice flakes. It ran for three months throughout. And it had five groups of 15, with groups on cinnamon and garlic that the 2014 report leaves out [46].

None of that tells us what happened, or why, and we draw no conclusion about it. It tells us the 2014 report does not add up on its own pages and repeats the thesis’s results rather than adding to them, and that is enough for this page not to lean on it.

So the thesis is the trial to weigh, and it comes close to the one this page would ask for. Men with diabetes and raised blood fats, picked out by a doctor, took four capsules a day holding 2 g of powdered cloves, about a teaspoon by our arithmetic [14], for three months. Their fasting blood sugar went from 163.9 to 124.2 mg/dL and their HbA1c from 8.1% to 7.25%; on the dummy capsules, from 165.9 to 165.3 and from 7.85% to 7.84% [46]. We do not rely on it either, for reasons in its own methods chapter. The men were chosen for their “willingness to participate and co-operate” and then “divided” into groups, with no randomisation described, so the clove group and the dummy group may have differed from the start in ways that matter. No blinding is described: nothing says whether the men, or the people measuring them, knew who was taking what. It was men only, at one workplace. It does not say what diabetes treatment the men were on or whether it changed during the three months; in the survey the trial drew its men from, all but 7.5% of the 255 adults with both conditions were already being treated [46]. A university ethics committee approved it, it names no funder, and it is a thesis, not a paper checked by a journal’s reviewers [46].

Cloves have also been eaten in spice mixes, and the tests we found point both ways. In a 2015 American trial, 20 overweight adults, 6 of them women, ate a high-fat meal with and without 14.5 g of nine spices, about 0.6 g of it cloves (under a third of a teaspoon, by our arithmetic [14]), in random order, each after two days of matching meals; the spices made no difference to blood sugar or insulin afterwards [41]. It was supported mainly by a research institute funded by a spice company, whose sample programme donated the spices, and in part by US government grants [41] [42]. An earlier test of the same nine spices, with the same amount of cloves, in six overweight American men in 2011, found no difference in blood sugar but 21% less insulin after the spiced meal; the same institute supported it and supplied the spices [47]. In Japan in 2014, a curry made with eight spices, 0.9 g of them cloves, made no difference to blood sugar or insulin an hour after the meal in 14 healthy men; a Japanese food company ran it and paid for it, and six of the seven authors worked for that company or its group [48]. In Singapore in 2019, 20 young Chinese men ate rice with a vegetable curry made with two doses of seven spices, clove among them, or a control meal matched for calories and vegetables: the rise in blood sugar over the three hours after the meal was 19% smaller on the lower dose and 32% smaller on the higher, the fall in insulin was not clear enough to rule out chance, and blood fats after the meal rose with the dose; a Singapore government research agency paid for it [49]. And a 2025 conference abstract from Malaysia gave 30 people with type 2 diabetes, none of them on diabetes medicine, capsules of eight spices and herbs, cloves among them, at 2, 4 or 6 g a day for 30 days, with no comparison group; it reports only faint links between the dose and blood sugar or HbA1c [50]. In every one of these, cloves were one ingredient among several, so none can say what cloves did, and we count none of them for or against cloves.

Two reviews have looked for more. A 2024 review searched three databases to September 2023 for trials of a dozen Mediterranean spices, clove among them, in people with type 2 diabetes; for clove, “not enough studies were found” [20]. A 2023 review of spices at kitchen doses, three of whose four authors work for an herbal-tea company, says in its summary that it found “No relevant research” for cloves [21]. Neither review found anything to analyse, which is an absence of evidence, not evidence against.

For comparison, the site’s apple cider vinegar verdict finds vinegar’s effect on blood sugar after a meal in a pooled analysis of controlled trials, and its berberine verdict reports a double-blind trial of 300 adults in which berberine lowered fasting blood sugar more than a dummy did. Whole cloves have nothing like either that we can rely on.

Does clove help with H. pylori?

H. pylori is a bacterium that lives in the stomach lining of about half the world’s people and is a major cause of stomach ulcers [3]. The video’s reference for it is a 2005 study from India. In flasks of broth, eugenol stopped the growth of all 30 strains (genetic varieties) it was tried on at 2 micrograms per milliliter, worked better when the broth was made acidic, and the bacteria did not become resistant to it over 10 rounds of growth [3]. That is where “survives stomach acid” comes from. It was a flask, not a stomach, and its authors wrote that “clinical trials would be needed” [3].

Since then there have been more dish studies of clove extracts [22] and studies in mice [23]. The mouse study tested beta-caryophyllene, another compound found in cloves, and six of its ten authors give a Korean biotechnology company as their employer, and the paper says the compound it tested was obtained from that company [23].

In people we found one trial [6]. In Korea, 66 adults with the infection took a capsule of beta-caryophyllene, 126 mg a day, or a dummy capsule of corn oil, for eight weeks; 59 finished [9]. The infection cleared in nobody, in either group. The compound group reported less nausea and less upper-stomach pain at eight weeks than at the start. But the dummy group’s nausea fell at least as far, both groups started at about 1 or less on a 0-to-10 scale, and the paper compares the groups only at the start, never in how far their symptoms changed [9]. The paper declares no funding and no conflicts, and does not say where its beta-caryophyllene came from; it names cloves as one of several plants that contain it [9]. We found no trial that gave people cloves, clove water, clove oil or eugenol for H. pylori [6].

Do cloves heal stomach ulcers or help digestion?

In rats, often. Clove oil and eugenol protected rats’ stomachs against ulcers caused by alcohol and by an anti-inflammatory drug [24], and the extract’s maker reported the same for its extract in rats [16]. But the dose matters, and not in the direction a daily habit would want: in a 2021 rat study, a low dose of eugenol sped the healing of ulcers made with acid, while a dose a hundred times higher made the ulcers 49% bigger [25].

In people, the only report we found is from 1951: eugenol given to patients with peptic ulcers [26]. We could not read it. It has no abstract, the publisher refused automated reading, and the Internet Archive holds no copy [26]. We found no modern trial [6].

“Supports digestion” has even less. We found no study we could rely on that gave people cloves on their own and measured anything about digestion [6]. The 2014 report above lists constipation among the symptoms it says were gone after three months of cloves, with no numbers, and for the reasons above we do not lean on it [38]. The thesis it repeats counted one man with constipation among the 15 on cloves before, and none after, with none in the dummy group either time [46]. Trials of herbal mixtures that include cloves exist; in the one we read, a 2019 Iranian capsule that eased constipation in women after menopause, cloves were a small share of nine ingredients that included senna, itself a laxative [43]. The Korean trial’s nausea and stomach-pain result, for a single compound in a capsule, was a change within the group that the paper never compared with its dummy group, whose nausea fell at least as far [9]. What points the claim’s way is in animals and dishes. A Thai herbal remedy whose largest ingredient is clove buds stopped diarrhea in mice, and in cell tests its clove and agarwood extracts did most of the work of blocking the channels the gut lining uses to pour out fluid in diarrhea [44]. And eugenol relaxed segments of mouse gut in a dish [45].

The description adds that eugenol works on the upper gut “because the vast majority of this compound doesn’t make it past the liver” [1]. Here is what was measured. In volunteers, eugenol was absorbed quickly and almost all of it left in the urine within a day, nearly all of it after the body had bound it to other molecules to clear it [27]. So eugenol does not stay in the gut: it is absorbed, changed and cleared within a day. Whether any of it acts on the upper gut on the way through is not something those measurements show, and none of the three papers the description lists measured it [2] [3] [4].

Did anyone test clove in coffee?

Not that we could find [6]. The closest is a 2023 trial in Saudi Arabia of Arabic coffee, brewed from a liter of water, three tablespoons of coffee, a teaspoon of cardamom, half a teaspoon of ground cloves and a quarter teaspoon of saffron [7]. In all, 140 adults with mildly raised blood pressure were split between drinking 1 oz (30 mL) of it four times a day for four weeks, and avoiding it [7]. It measured blood pressure and blood fats; it did not measure blood sugar [7]. By our arithmetic, the coffee group’s daily cups were brewed with about an eighth of a gram of clove [14].

How much eugenol does a crushed clove give a cup of coffee in two minutes? We found no measurement [6]. The description also says “Coffee has its own benefits and supports healthy blood glucose levels” [1]. Coffee and blood sugar is a separate question that this page does not weigh; the site’s coffee verdict covers coffee and weight.

Is it good to eat cloves, or drink clove water, every day?

In the amounts used to flavor food, the regulators see no problem. The expert committee on food additives run jointly by two UN agencies, the Food and Agriculture Organization and the World Health Organization, set an acceptable daily intake for eugenol in 1982: up to 2.5 mg per kilogram of body weight a day [28]. That is the amount a person could take every day for life without appreciable risk, and here it is a hundredth of the highest daily dose that did no harm in rats [28]. Europe’s food safety authority agreed in 2009 that eugenol used as a flavoring raises “No safety concern at estimated levels of intake” [29], and the US Food and Drug Administration lists cloves and eugenol as generally recognized as safe as flavoring agents [10].

Put that in kitchen terms. For a 154 lb (70 kg) adult, 2.5 mg per kilogram is 175 mg of eugenol a day. At 94 to 147 mg of eugenol per gram of clove, that is 1.2 to 1.9 g of cloves, a little over half a teaspoon to just under a teaspoon of ground cloves, by our arithmetic [13] [14]. The 2006 abstract’s top dose, 3 g a day, would carry 1.6 to 2.5 times that intake for the same adult, also by our arithmetic [17]. A clove steeped for two minutes gives up some share of its eugenol; we found no measurement of how much [6].

What the regulators settle is flavoring. A daily medicinal dose of cloves is not what they assessed; clove oil swallowed by the spoonful is not covered; and a safety listing is not evidence of a benefit [29] [10]. Clove water is the same arithmetic in a different cup, and we found no trial of it [6].

What not to mix with cloves?

Clove oil and small children, first. A 3-month-old who swallowed under two teaspoons (less than 8 mL) of clove oil went into liver failure and recovered after treatment [30]; so did a 15-month-old who swallowed two teaspoons (10 mL) [31]; a 2-year-old developed a dangerous clotting disorder alongside liver damage [32]. That is concentrated oil, not a clove. By our arithmetic, two teaspoons (10 mL) of clove-bud oil carries about 7.7 to 8.0 g of eugenol, the amount in roughly 2 to 3 oz (53 to 86 g) of whole cloves [12] [13]. Keep clove oil where children cannot reach it.

Blood thinners. In a dish, eugenol stops blood platelets clumping, more strongly than aspirin in one test [33]. A pharmacists’ review of herbs and warfarin lists clove among those that “may potentially” raise the risk of bleeding, and says nearly all such warnings rest on dish studies, animal studies or single case reports [34]. We found no reported case of anyone bleeding from cloves taken with a blood thinner [6]. That is a gap, not a clearance: if you take one and plan a daily medicinal amount of cloves, tell whoever prescribes it.

Diabetes medicine. Google’s AI answer warns that eugenol can drop blood sugar too low alongside diabetes medications [5]. The evidence near that warning is the thin blood-sugar record above and a rat study, in which eugenol raised blood levels of the diabetes drug repaglinide and lowered blood sugar further in diabetic rats [35]. We found no such case in a person [6]. The same advice applies.

Cloves are sold for one more stomach job. The site’s parasite cleanse verdict found them in a 1993 book’s parasite-killing recipe and on the label of capsules named in a 2023 FDA warning letter, and found no trial of clove against parasites in people.

Who these studies were done on

Studies in people on this page that gave cloves, clove extract or a clove compound by mouth, and the nearest test of clove in coffee
Who What they took, and for how long What happened
13 adults aged 25 to 35 in India, 10 men and 3 women; 6 with raised blood sugar before lunch [4]A 250 mg capsule of a clove extract after lunch for 30 days; nobody given a dummy capsuleBlood sugar two hours after lunch fell in both groups; before lunch, only in the raised group
70 adults with metabolic syndrome; 64 finished [37]250 mg a day of the same clove extract, or 250 mg of synthetic glutathione, an antioxidant supplement, for 84 daysFasting and after-meal blood sugar and HbA1c fell further on the extract, by the paper’s summary and charts; we could not read its full text
36 adults with type 2 diabetes in Pakistan [17]Capsules of 1, 2 or 3 g of cloves, or dummy capsules, for 30 daysBlood sugar fell in the clove groups and not in the dummy group; a meeting abstract, never published in full
75 men with diabetes and raised blood fats at one workplace in Coimbatore, India, in five groups of 15 [46]2 g of powdered cloves a day in capsules, or cinnamon, garlic or turmeric, or capsules of roasted Bengal gram flour, for three monthsHbA1c fell from 8.1% to 7.25% on cloves and stayed at about 7.85% on the dummy; no randomisation or blinding described, and we do not rely on it
45 adults with diabetes and raised blood fats in Surat, India, by the report’s own account [38]4 g of powdered cloves a day in capsules, or turmeric, or rice-flake capsules, for three months or two (the report says both)Repeats the thesis’s blood-sugar and HbA1c results to the decimal, with a different dose, dummy, town and length; does not add up on its own pages, and we do not rely on it
12 healthy adults in Denmark, mostly women, aged 25 to 63 [19]1 g of ground cloves on rice pudding at breakfast and 3 g at lunch, one dayNo difference from plain rice pudding
59 adults with H. pylori in Korea, average age about 55 [9]126 mg a day of beta-caryophyllene, a compound found in cloves, or a dummy capsule, for eight weeksNobody cleared the infection in either group; symptoms eased from the start on the compound, and nausea fell at least as far on the dummy
140 adults with mildly raised blood pressure in Saudi Arabia [7]Coffee brewed with cardamom, cloves and saffron, or no such coffee, for four weeksMeasured blood pressure and blood fats; did not measure blood sugar
Each row is a separate study with its own people, doses and measures; the rows are not one league table. None of those we read in full reported its results for women and men separately, and none put a clove in coffee. These are averages for groups, not a forecast for any one person. Not in the table: the tests of spice mixes with cloves in them, because none can single out cloves; the 2012 Coimbatore trial, which measured blood fats, not blood sugar; the 2010 paper we could not read; the 2019 Iranian nine-herb constipation capsule; the volunteers given eugenol to see how the body clears it; the clove-mouthwash trial; and the case reports of poisoning.

Readers search for clove benefits “for women” and “for men” [5]. None of the studies we read in full reported its results for women and men separately [4] [17] [19] [9] [38] [41], and the 2022 extract trial’s summary and charts do not either [37], so there is no answer to either search here. The 2008 thesis, which we do not rely on, chose men only, on purpose [46]. The 13-person study, the one the video cites, was in young adults in India eating a south Indian lunch [4]; the same extract was tested again in 2022 in adults with metabolic syndrome, with the limits set out above [37].

So what lowered blood sugar in the study the video cites?

This section is the desk’s own reasoning, and it is labelled as such. The 13-person study found a fall; its design cannot say why. Here are three answers, each rated for how much evidence sits under it.

Answer one: possibly nothing the capsule did. With no comparison group, the fall could be people eating differently once they were watched, or high first readings drifting back down by themselves, and the second group was picked precisely because its first reading was higher [4]. The 2022 trial of the same extract, against another supplement, reported falls too, which would make this less likely to be the whole story if that trial could be taken at face value; it had no dummy group, and its charts do not all agree with each other, as set out above [37]. This is a surmise, and the study’s design cannot rule it out.

Answer two: if the capsule did it, probably not eugenol. The extract was made to minimise a clove’s taste and smell, in the maker’s words [8] [16], and a clove’s smell and bite are in its oil, which is mostly eugenol [11] [12]. That the extract was built this way is measured, in the maker’s own descriptions; that its polyphenols rather than its leftover eugenol did the work is a surmise, because nobody measured either.

Answer three: a crushed clove in coffee is a different dose of a different thing. The capsule held 250 mg of extract at 30% to 41% polyphenols [4] [11], about 75 to 103 mg of polyphenols. Buds used for the extract were 11.5% polyphenols in the maker’s safety study [11], so the capsule matches roughly 0.65 to 0.9 g of cloves, if every polyphenol came out. How much a crushed clove gives up to coffee in two minutes, nobody we found has measured [6]. This is arithmetic with a hole in it, and we mark it as ours.

Put the three together and here is what we think is true, stated plainly so you can disagree with it: a clove in your coffee is a flavor, and the blood-sugar study the video attaches to it tested a capsule of an extract its maker calls de-flavoured.

What we could not find, and would like to: a trial we can rely on that gives adults with raised blood sugar whole cloves or a clove drink, or a dummy that tastes the same, for three months or more, and measures HbA1c, reported so that its numbers can be checked. One trial of nearly that design is reported, in a 2008 thesis that describes no randomisation or blinding, and again in a 2014 report that repeats its results with a different account of the trial; for the reasons above we rely on neither [46] [38]. Also a measurement of how much eugenol and polyphenol a crushed clove gives up to a cup of coffee in two minutes, and a published weight for a single dried clove. If you know of any of them, the corrections line on this site is open.

Where “a clove in your coffee” came from

The research came first, from the extract’s maker. The 13-person study ran in 2014 and was published in 2019; its conclusion says the findings “underscore the therapeutic utility” of the extract and, in the same sentence, that they “warrant further larger-scale clinical trials” [4]. A larger trial of the extract followed in 2022, again with the maker’s staff among its authors, against another supplement rather than a dummy [37].

The framing came with it. The study’s title says the extract “lowers” blood sugar, a verb that needs a comparison group behind it, and a US supplement company that sells finished products containing the extract had two employees among its authors [4].

Then the spread. The video, on 16 September 2026, put the study among its three references and turned it into a clove in your coffee [1]. Google’s AI answer for “clove benefits” now cites the video [5]. Eleven days after the video, a fitness website’s “research brief” on the clove-coffee claims listed one as “30-day eugenol supplementation reduced blood sugar in pre-diabetics” and marked it “Mixed evidence”, naming no study [36]. The 30-day study was of an extract its maker calls de-flavoured, not of eugenol [4] [8].

And the product. The study’s own paper says the US supplement company whose employees co-wrote it sells finished products containing the extract [4], and the video’s description advertises its creator’s own supplement line [1].

None of this is aimed at anyone with a clove in their coffee. It is a pleasant way to flavor a cup, and in those amounts the regulators see no harm. It is the step from a 13-person capsule study to a daily fix for your blood sugar that the evidence does not carry.

What this is rated, and what the rating covers

Preliminary — for the claim that a clove a day, in coffee or otherwise, lowers blood sugar.

It is rated Preliminary because the evidence is early, small and conflicting. In its favor: two studies of an extract that is not a clove, both with the maker’s staff among the authors: a 13-person study with no comparison group, paid for by the maker [4], and a 70-person trial against another supplement, whose charts do not all agree with each other and which we could read only as its summary and charts [37]. For whole cloves: a 2006 meeting abstract of 1 to 3 g in 36 people that was never published in full [17], and a 2008 doctoral thesis in which HbA1c fell over three months in 15 men taking 2 g of cloves a day and not in 15 taking dummy capsules, in a trial that describes no randomisation or blinding [46]; a 2014 report repeats the thesis’s results, with a different account of how the trial was run, and adds no evidence of its own [38]. Against it: the one test of cloves on their own eaten as food, which found nothing after a meal [19]. Tests of spice mixes with cloves in them point both ways, and none can single out cloves, so none is counted [41] [47] [48] [49] [50]. Two reviews looked and found too little to analyse, which is an absence of evidence, not evidence either way [20] [21]. Of the whole-clove trials we found, only one lasted more than 30 days or measured HbA1c, the thesis’s, which the 2014 report repeats, and we do not rely on it; none put a clove in coffee [17] [19] [46]. So for cloves themselves the rating sits low in that tier: what points their way is an abstract and a thesis, neither of them a paper checked by a journal’s reviewers, and the one meal test of cloves alone found nothing. A randomised, blinded trial of whole cloves against a dummy for three months, measuring HbA1c and reported so that its numbers can be checked, could move it either way.

Rated alone, in words. That cloves or eugenol help against H. pylori: Preliminary; no trial we found gave people cloves or eugenol for it, dish studies of eugenol and clove extracts and a mouse study of beta-caryophyllene point its way, and the one trial of that compound in infected people cleared no infections [3] [22] [23] [9]. That cloves heal ulcers: Preliminary; untested in people since a 1951 report we could not read, mostly protective in rats, and in rats a high dose of eugenol made ulcers bigger [26] [24] [25]. That clove coffee supports digestion: Preliminary, and only just; untested in people in any form we could rely on, with animal and dish evidence in its favor, a remedy made mostly from clove buds that stopped diarrhea in mice, and eugenol relaxing mouse gut [44] [45]. The one human result for a clove compound, less nausea and stomach pain than at the start, was matched on nausea by its dummy group [9].

What is not rated here: the description’s other claims (dental pain, antifungal, liver and anti-inflammatory effects, antioxidants), coffee’s own effect on blood sugar, clove oil as a treatment for anything, and the frame above, which is this desk’s reasoning from the evidence rather than a result the evidence delivered. It is marked as ours so that you can weigh it as ours.

This is journalism, not medical advice. None of this is a reason to stop, skip or swap a diabetes medicine, and if your blood sugar is raised, that belongs with a clinician. How we read a study, and what each tier means, is set out here.

Sources
[1] A chiropractor’s health-video channel, whose creator directs a supplement company advertised in every description: “1 CLOVE in Your Coffee Every Morning (Here’s What Happens)”, published 16 September 2026, 6,176,664 views. Title, date, view count and description, with its three listed references, read through the YouTube Data API on 10 October 2026; we read the description, not the video’s audio. The channel is described by its role, not its name.
[2] Jahanshir M, Nobahar M, Ghorbani R, Malek F. Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial. Clinical Oral Investigations 2023;27(7):3589–3600. 168 patients in an Iranian hospital, clove mouthwash against chlorhexidine. One of the three references in the video’s description. Read in full on PubMed Central; used here only for what it tested. doi:10.1007/s00784-023-04972-w
[3] Ali SM, Khan AA, Ahmed I, Musaddiq M, Ahmed KS, Polasa H, et al. Antimicrobial activities of eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Annals of Clinical Microbiology and Antimicrobials 2005;4:20. A laboratory study of 30 strains. One of the three references in the video’s description. Read in full on PubMed Central. Supported by India’s University Grants Commission. doi:10.1186/1476-0711-4-20
[4] Mohan R, Jose S, Mulakkal J, Karpinsky-Semper D, Swick AG, Krishnakumar IM. Water-soluble polyphenol-rich clove extract lowers pre- and post-prandial blood glucose levels in healthy and prediabetic volunteers: an open label pilot study. BMC Complementary and Alternative Medicine 2019;19(1):99. 13 volunteers. One of the three references in the video’s description. Read in full on PubMed Central. Paid for by the extract’s maker, an Indian flavor company that employs two of the authors; two more are employed by a US supplement company that sells finished products containing the extract, and two work at an Indian college. By the paper’s own account, one of the maker’s employees and the supplement company’s two analysed the data and wrote the paper, and the college authors ran the experiments and collected the data. doi:10.1186/s12906-019-2507-7
[5] Search data from a paid keyword database, pulled 10 October 2026: monthly search volumes for the United States, and Google’s results, People Also Ask questions, related searches and AI answer for “clove benefits”. Kept with this page’s records.
[6] The desk’s searches, 10 October 2026: PubMed by title and abstract in at least two wordings for each question on this page (clove, cloves, Syzygium aromaticum, Eugenia caryophyllata, eugenol and the extract’s trade name, with blood sugar, glucose, diabetes, insulin, H. pylori, ulcer, gastritis, dyspepsia, digestion, coffee, tea, infusion, bleeding, warfarin and hypoglycemia terms; 166 records for the blood-sugar search, every title read); Europe PMC’s full texts; Crossref; ClinicalTrials.gov and the ISRCTN registry; the studies listed by the reviews in [20] and [21] and by a 2026 review of spices eaten in food; and one ordinary web search per question, its first page read. The record is kept with this page.
[7] Jalal SM, Alsebeiy SH, Aleid HA, Alhamad SA. Effect of Arabic qahwa on blood pressure in patients with stage one hypertension in the eastern region of Saudi Arabia. Journal of Personalized Medicine 2023;13(6):1011. 140 adults. Read in full on PubMed Central. Funded by King Faisal University’s research deanship; no conflicts declared. doi:10.3390/jpm13061011
[8] Johannah NM, Renny RM, Gopakumar G, Maliakel B, Sureshkumar D, Krishnakumar IM. Beyond the flavour: a de-flavoured polyphenol rich extract of clove buds (Syzygium aromaticum L) as a novel dietary antioxidant ingredient. Food & Function 2015;6(10):3373–3382. Read as its published abstract; the full text is behind the publisher’s paywall. Written at the extract maker’s research centre. doi:10.1039/c5fo00682a
[9] Shim HI, Song DJ, Shin CM, Yoon H, Park YS, Kim N, Lee DH. Inhibitory effects of β-caryophyllene on Helicobacter pylori infection: a randomized double-blind, placebo-controlled study. Korean Journal of Gastroenterology 2019;74(4):199–204. 66 adults randomised, 59 finished. Read in full in the journal’s PDF, in Korean with an English abstract. No financial support and no conflicts declared. doi:10.4166/kjg.2019.74.4.199
[10] US Code of Federal Regulations, Title 21, section 184.1257, “Clove and its derivatives”: cloves, clove oils and eugenol are generally recognized as safe as flavoring agents and adjuvants, at levels not to exceed good manufacturing practice. Read in full in the electronic CFR, version of 1 September 2026.
[11] Vijayasteltar L, Nair GG, Maliakel B, Kuttan R, Krishnakumar IM. Safety assessment of a standardized polyphenolic extract of clove buds: subchronic toxicity and mutagenicity studies. Toxicology Reports 2016;3:439–449. Studies in rats; describes how the extract in [4] is made and what is in it. Read in full on PubMed Central. Paid for by the extract’s maker, which employs three of the five authors; the authors declare no conflicts. doi:10.1016/j.toxrep.2016.04.001
[12] EFSA Panel on Additives and Products or Substances used in Animal Feed. Safety and efficacy of feed additives consisting of essential oils derived from the flower buds or the leaves of Syzygium aromaticum (clove bud oil and clove leaf oils) for all animal species. EFSA Journal 2023;21(7):e08183. Used here only for its analysis of clove-bud oil: eugenol 73.0% to 76.0% of seven batches by chromatography, specific gravity 1.056 to 1.059. Read in full on PubMed Central. doi:10.2903/j.efsa.2023.8183
[13] Phenol-Explorer, version 3.6, polyphenol contents of cloves: eugenol, mean 12,592.93 mg per 100 g of cloves as sold, ranging from 9,381.70 to 14,650.00 across four measurements from two published sources. Read 10 October 2026.
[14] US Department of Agriculture, FoodData Central, SR Legacy food 171321, “Spices, cloves, ground”: one teaspoon weighs 2.1 g. Read 10 October 2026.
[15] ISRCTN15680985. The registry record of the study in [4]: an open-label pilot, recruiting from 5 to 20 September 2014 and ending 23 October 2014, sponsored by the extract’s maker. Its lay summary says the study was funded by and run at the maker’s research centre, and it states the hypothesis of falls of 5 and 40 mg/dL before and after meals. Entered 28 September 2018, last updated 9 May 2019. Record read through the registry’s data interface, 10 October 2026.
[16] Issac A, Gopakumar G, Kuttan R, Maliakel B, Krishnakumar IM. Safety and anti-ulcerogenic activity of a novel polyphenol-rich extract of clove buds (Syzygium aromaticum L). Food & Function 2015;6(3):842–852. Studies in rats and mice. Read as its published abstract; four of the five authors give the extract maker’s research centre as their address. Its funding statement was not read: the publisher’s site refused automated reading, and Crossref lists no funder. doi:10.1039/c4fo00711e
[17] Khan A, Qadir SS, Khattak KN, Anderson RA. Cloves improve glucose, cholesterol and triglycerides of people with type 2 diabetes mellitus. FASEB Journal 2006;20(5):A990. A meeting abstract from Experimental Biology 2006; 36 people. Read in full in the Internet Archive’s copy of the publisher’s page; the publisher’s site refused automated reading. Supported by the Higher Education Commission of Pakistan. doi:10.1096/fasebj.20.5.A990-b
[18] American Diabetes Association. Expression of concern on “Cinnamon improves glucose and lipids of people with type 2 diabetes” (Diabetes Care 2003;26:3215–3218). Diabetes Care 2025;48(9):1646, published 20 August 2025. Read in full in the Internet Archive’s copy of the journal’s page; the journal’s site refused automated reading. doi:10.2337/dc25-ec09
[19] Klarskov CK, Brøsen JMB, Olsen MT, She R, Fabricius TW. Julekrydderiers indflydelse på blodsukkeret efter indtagelse af risengrød målt med kontinuerlig glukosemonitorering (Christmas spices and blood sugar after rice pudding, measured by continuous glucose monitoring). Ugeskrift for Læger 2021;183:V20216. 12 healthy adults. Read in full in the journal’s own copy, in Danish. No funding and no conflicts declared.
[20] Garza MC, Pérez-Calahorra S, Rodrigo-Carbó C, Sánchez-Calavera MA, Jarauta E, Mateo-Gallego R, et al. Effect of aromatic herbs and spices present in the Mediterranean diet on the glycemic profile in type 2 diabetes subjects: a systematic review and meta-analysis. Nutrients 2024;16(6):756. Searched to September 2023. Read in full on PubMed Central. Funded by the government of Aragon and the Spanish economy ministry; no conflicts declared. doi:10.3390/nu16060756
[21] Mackonochie M, Rodriguez-Mateos A, Mills S, Rolfe V. A scoping review of the clinical evidence for the health benefits of culinary doses of herbs and spices for the prevention and treatment of metabolic syndrome. Nutrients 2023;15(23):4867. Searched in January 2023. Read in full on PubMed Central: its summary and its table of included studies hold no clove study, though two sentences, one in its results and one in its discussion, list cloves among the spices with evidence or studies. No external funding; three of the four authors are employed by an herbal-tea company. doi:10.3390/nu15234867
[22] Peng C, Sang S, Shen X, Zhang W, Yan J, Chen P, et al. In vitro anti-Helicobacter pylori activity of Syzygium aromaticum and the preliminary mechanism of action. Journal of Ethnopharmacology 2022;288:114995. A laboratory study. Read as its published abstract. doi:10.1016/j.jep.2022.114995
[23] Jung DH, Park MH, Kim CJ, Lee JY, Keum CY, Kim IS, et al. Effect of β-caryophyllene from cloves extract on Helicobacter pylori eradication in mouse model. Nutrients 2020;12(4):1000. 160 mice. Read as its abstract, author list and declarations on PubMed Central: six of the ten authors give a Korean biotechnology company as their employer and one a Korean drug company; it says the compound tested was obtained from that biotechnology company; funded by a Korean government programme for small companies; no conflicts declared. doi:10.3390/nu12041000
[24] Santin JR, Lemos M, Klein-Júnior LC, Machado ID, Costa P, de Oliveira AP, et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn-Schmiedeberg’s Archives of Pharmacology 2011;383(2):149–158. Rats. Read as its published abstract. doi:10.1007/s00210-010-0582-x
[25] Longo B, Sommerfeld EP, dos Santos AC, da Silva RCMVAF, Somensi LB, Mariano LNB, et al. Dual role of eugenol on chronic gastric ulcer in rats: low-dose healing efficacy and the worsening gastric lesion in high doses. Chemico-Biological Interactions 2021;333:109335. Rats. Read as its published abstract. doi:10.1016/j.cbi.2020.109335
[26] Bandes J, Samuels NA, Hollander F, Goldfischer RL, Winkelstein A. The clinical response of patients with peptic ulcer to a topical mucigogue (eugenol). Gastroenterology 1951;18(3):391–399. Not read: it has no abstract, the publisher’s site refused automated reading, and the Internet Archive holds no copy. doi:10.1016/s0016-5085(51)80005-2
[27] Fischer IU, von Unruh GE, Dengler HJ. The metabolism of eugenol in man. Xenobiotica 1990;20(2):209–222. Healthy volunteers. Read as its published abstract. doi:10.3109/00498259009047156
[28] Joint FAO/WHO Expert Committee on Food Additives. Eugenol. WHO Food Additives Series 17, monograph 530, 1982. Sets the acceptable daily intake of 0 to 2.5 mg per kg of body weight from a no-effect level of 250 mg per kg in rats. Read in full in the copy on the International Programme on Chemical Safety’s INCHEM site.
[29] European Food Safety Authority, Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. Flavouring Group Evaluation 60: consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting). EFSA Journal 2009;965. Adopted 1 April 2008; records that JECFA kept its acceptable daily intake at that meeting. Read in full in the Internet Archive’s copy; the authority’s site refused automated reading. doi:10.2903/j.efsa.2009.965
[30] Eisen JS, Koren G, Juurlink DN, Ng VL. N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure. Journal of Toxicology: Clinical Toxicology 2004;42(1):89–92. One infant. Read as its published abstract. doi:10.1081/clt-120028751
[31] Janes SE, Price CS, Thomas D. Essential oil poisoning: N-acetylcysteine for eugenol-induced hepatic failure and analysis of a national database. European Journal of Pediatrics 2005;164(8):520–522. One child. Read as its published abstract. doi:10.1007/s00431-005-1692-1
[32] Brown SA, Biggerstaff J, Savidge GF. Disseminated intravascular coagulation and hepatocellular necrosis due to clove oil. Blood Coagulation & Fibrinolysis 1992;3(5):665–668. One child. Read as its published abstract. doi:10.1097/00001721-199210000-00025
[33] Raghavendra RH, Naidu KA. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins, Leukotrienes and Essential Fatty Acids 2009;81(1):73–78. Human platelets in a dish. Read as its published abstract. doi:10.1016/j.plefa.2009.04.009
[34] Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. American Journal of Health-System Pharmacy 2000;57(13):1221–1227. A review. Read as its published abstract. doi:10.1093/ajhp/57.13.1221
[35] Zhao Z, Zhang S, Li S, Sun L. Drug-drug interaction between eugenol and repaglinide in type 2 diabetes mellitus and its potential mechanism. Journal of Visualized Experiments 2026;(233). Diabetic rats. Read as its published abstract. doi:10.3791/72128
[36] A fitness website’s “Research Brief: Clove in Coffee Claims”, dated 27 September 2026, read 10 October 2026. Described by its role; cited as evidence of how the claims are retold, not as evidence about cloves.
[37] Thomas J, Patel A, Das Sivadasan S, Sreevallabhan S, Illathu Madhavamenon K, Mohanan R. Clove bud (Syzygium aromaticum L.) polyphenol helps to mitigate metabolic syndrome by establishing intracellular redox homeostasis and glucose metabolism: a randomized, double-blinded, active-controlled comparative study. Journal of Functional Foods 2022;98:105273. 70 adults randomised, 64 finished. Read as its published abstract, author list and figures, in the Internet Archive’s copy of the publisher’s page and on the publisher’s image server; the paper is free to read on the publisher’s site, which refused our automated reading of the full text, so its tables and its funding statement were not read. Two of the six authors give the extract maker’s research centre as their address, and the first author a contract research company. Not indexed in PubMed. doi:10.1016/j.jff.2022.105273
[38] Tripathi MA, Tripathi A, Sharma V. Effect of cloves and turmeric on hyperlipidemic diabetics. International Journal for Pharmaceutical Research Scholars 2014;3(1):599–606. 45 adults. Read in full in the journal’s own PDF, 10 October 2026. Not indexed in PubMed or Europe PMC, and Crossref holds no record of it. It does not say how people were put into groups, and it states no funding, no ethics approval and no consent.
[39] Balasasirekha R, Lakshmi UK. Effect of cloves and turmeric on hyperlipidemics. Journal of Human Ecology 2012;37(2):125–132. A survey of 500 adults employed at an industrial firm in Coimbatore, India, and a three-month trial in 45 of them with raised blood fats, of 2 g a day of cloves or turmeric or capsules of powdered sugar; it measured blood fats, weight and symptoms, not blood sugar. Read in full in the publisher’s PDF. doi:10.1080/09709274.2012.11906456
[40] Balasasirekha R, Lakshmi UK. Effect of cloves and turmeric on hyperlipidemic diabetics. The Indian Journal of Nutrition and Dietetics 2010;47(4):129–136. Not read: we saw it only in the journal’s April 2010 contents, as an ordinary web search displays them. The journal’s site and its mirror served a bot check, which we did not pass; Crossref, PubMed and Europe PMC hold no record of it, and the Internet Archive holds no copy.
[41] McCrea CE, West SG, Kris-Etherton PM, Lambert JD, Gaugler TL, Teeter DL, et al. Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments. Journal of Translational Medicine 2015;13:7. 20 adults. Read in full on PubMed Central. Supported mainly by a research institute funded by a spice company [42], whose sample programme donated the spices, and in part by US National Institutes of Health grants; three of the ten authors report research, travel or honorarium support from the institute. doi:10.1186/s12967-014-0360-5
[42] Faridi H, Johnson GH. The McCormick Science Institute: mission, funding guidelines, governance, and 20 years of contributions to the research and public health communities pertaining to spices and herbs. Nutrition Reviews 2026;84(Suppl 1):1–2. Used only for its statement that the institute is fully funded by a spice company. Read in full on PubMed Central. doi:10.1093/nutrit/nuaf185
[43] Eliasvandi P, Khodaie L, Mohammad Alizadeh Charandabi S, Mirghafourvand M. Effect of an herbal capsule on chronic constipation among menopausal women: a randomized controlled clinical trial. Avicenna Journal of Phytomedicine 2019;9(6):517–529. 64 women. Read in full on PubMed Central. From a master’s thesis project; no conflicts declared. doi:10.22038/AJP.2019.13109
[44] Tradtrantip L, Ko EA, Verkman AS. Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy. PLoS Neglected Tropical Diseases 2014;8(2):e2674. Mice and cells. Read in full on PubMed Central. US National Institutes of Health grants and a research grant from a cystic-fibrosis charity; the remedy was bought; no competing interests declared. doi:10.1371/journal.pntd.0002674
[45] Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS. Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-activated Cl- channel TMEM16A. PLoS ONE 2012;7(5):e38030. Cells and mouse gut tissue. Read in full on PubMed Central. US National Institutes of Health grants; no competing interests declared. doi:10.1371/journal.pone.0038030
[46] Balasasirekha R. Effect of selected spices on hyperlipidemic and diabetic adults. Doctoral thesis, Avinashilingam University for Women, Coimbatore, India, September 2008; supervised by Lakshmi UK. Held in the university’s open repository (handle avu/115). Its trial in men with diabetes and raised blood fats is the one whose results the report in [38] repeats. Read: its methods, results and summary chapters, its appendices of each man’s readings (scanned tables, read as images), and its front pages, 10 October 2026; its introduction, literature review and bibliography were not read. It names no funder; its acknowledgements thank the two employers for permission to work on their premises; approved by the university’s ethics committee (HEC.2007.08). A thesis, not a journal paper.
[47] Skulas-Ray AC, Kris-Etherton PM, Teeter DL, Chen CY, Vanden Heuvel JP, West SG. A high antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men. Journal of Nutrition 2011;141(8):1451–1457. 6 men. Read in full on PubMed Central. Supported by the research institute described in [42], which is funded by a spice company; the spices came from the institute’s sample programme. A US National Institutes of Health grant supported the university’s research centre. The authors declare no conflicts. doi:10.3945/jn.111.138966
[48] Nakayama H, Tsuge N, Sawada H, Masamura N, Yamada S, Satomi S, Higashi Y. A single consumption of curry improved postprandial endothelial function in healthy male subjects: a randomized, controlled crossover trial. Nutrition Journal 2014;13:67. 14 men. Read in full on PubMed Central. Supported by a Japanese food company and run at its premises; six of the seven authors are employees of that company or its group. doi:10.1186/1475-2891-13-67
[49] Haldar S, Chia SC, Lee SH, Lim J, Leow MK, Chan ECY, Henry CJ. Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose–response randomized controlled crossover trial. European Journal of Nutrition 2019;58(1):301–313. 20 men. Read as its published abstract and its funding and conflict statements on the publisher’s page, with its trial registry record (NCT02599272), which names the spices; the full text is behind the publisher’s paywall, so how much clove the curry held was not read. Funded by a Singapore government research agency; no conflicts declared. doi:10.1007/s00394-017-1594-9
[50] Mahmood T, Mohd Shukri NA, Khattak MMAK. Supplementation of mixed spices for thirty days improved blood glucose levels and lipid profiles in a group of T2DM patients – a quasi-experimental study design. Asian Journal of Medicine and Biomedicine 2025;9(Suppl 1):31–34. An extended abstract from a 2023 conference; 30 people with type 2 diabetes. Read in full in the journal’s PDF. No comparison group; no funding statement found. The journal prints a DOI, 10.37231/ajmb.2025.9.S1.747, that did not resolve when we tried it on 10 October 2026, so none is linked here.